The aim of this study is to evaluate which dysregulated angiomiRs compose the specific proangiogenic microRNA signature of advanced laryngeal cancer and review the literature. Thirty-six samples from twelve patients with advanced laryngeal carcinoma were collected. Total RNA was extracted and microRNA global profiling was performed using Agilent Technologies Microarray Kit. Fifty-nine microRNAs were found to have significantly different expression levels. Eleven microRNAs from the whole group were sorted as regulators of tumor angiogenesis (angiomiRs): seven were up-regulated—miR-1246, miR-181b 5p, miR-18a 5p, miR-21 3p, miR-210 3p, miR-503 5p, miR-93 5p and four were down-regulated—miR148a 5p, miR-145 5p, miR-204 5p, miR-125b 5p. For none of those microRNAs we found heterogeneity in tumor tissue. We are the first to report the specific proangiogenic microRNA signature in advanced laryngeal carcinoma and we confirm and amplify findings from previous studies that expand our perception of a specific “molecular state” of angiogenesis that is distinctive only for laryngeal cancer.

这项研究的目的是评估哪些失调的angiomiRs组成了晚期喉癌的特异性促血管生成microRNA标志，并综述了文献。收集了十二例晚期喉癌患者的三十六份样本。提取总RNA，并使用安捷伦科技微阵列试剂盒进行microRNA全局分析。发现59个microRNA具有明显不同的表达水平。整组的11种microRNA被分类为肿瘤血管生成（angiomiRs）的调节剂：7种被上调-miR-1246，miR-181b 5p，miR-18a 5p，miR-21 3p，miR-210 3p，miR-503 5p，miR-93 5p和四个下调-miR148a 5p，miR-145 5p，miR-204 5p，miR-125b 5p。对于这些microRNA，我们都没有发现肿瘤组织具有异质性。