The skin, which serves as the first barrier of the human body, is particularly susceptible to exogenous injuries. Skin wounds, including acute burns and chronic non-healing ulcers, are commonly observed in clinics. Healing of skin wounds is a complex process, consisting of infiltration of inflammatory cells, cellular proliferation, and tissue remodeling phases, which restore the integrity and functions of the skin. Epithelialization is involved in wound healing through re-establishing an intact keratinocyte layer. Epidermal stem cells are indispensable for epithelialization, and they are regulated by multiple proinflammatory cytokines or growth factors. In this review, we summarize recent advances in the effect of these cytokines on migration, proliferation, and differentiation processes of epidermal stem cells. We also introduce promising therapeutic strategies targeting epidermal stem cells or related proinflammatory cytokines for patients with skin wounds.

中文翻译：

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促炎细胞因子调节伤口上皮化中的表皮干细胞。

皮肤作为人体的第一道屏障，特别容易受到外源性损伤。皮肤伤口，包括急性烧伤和慢性不愈合溃疡，在临床上很常见。皮肤伤口的愈合是一个复杂的过程，包括炎症细胞浸润、细胞增殖和组织重塑阶段，从而恢复皮肤的完整性和功能。上皮化通过重建完整的角质细胞层参与伤口愈合。表皮干细胞对于上皮化是不可或缺的，它们受到多种促炎细胞因子或生长因子的调节。在这篇综述中，我们总结了这些细胞因子对表皮干细胞迁移、增殖和分化过程影响的最新进展。我们还为皮肤伤口患者介绍了针对表皮干细胞或相关促炎细胞因子的有前途的治疗策略。