Deep seawater (DSW) has been investigated for its lipid-lowering effects, but clinical evidence is still far from conclusive. Therefore, this study was conducted to examine the effects of refined DSW (RDSW) on hypercholesterolemia. In this randomized, double-blind, placebo-controlled trial, 78 Korean participants were randomized to either an RDSW group that drank RDSW for 8 weeks or a placebo group. Clinical laboratory information was collected from all subjects at 0, 4, and 8 weeks. Both groups showed a significant reduction in total cholesterol (TC), whereas only the RDSW group demonstrated a significant decrease in low-density lipoprotein cholesterol (LDL-c) during the study. Stratified analysis of both groups revealed a significant reduction of TC in the moderately high TC subgroup. However, only the RDSW exhibited a significant decline of LDL-c in the high LDL-c subgroup. In addition, lipoprotein(a) decreased significantly in the RDSW group, but not in the placebo. RDSW did not affect other lipid profiles, including high-density lipoprotein cholesterol (HDL-c), triglyceride, free fatty acid, apolipoproteins, and other markers including inflammation marker, hematological parameters, blood and urine chemistry, and vital signs. RDSW improved lipid profiles by decreasing TC and LDL-c while maintaining HDL-c levels in people with hypercholesterolemia.

中文翻译：

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精制深海水改善高胆固醇血症患者的血脂水平：一项随机，双盲，安慰剂对照的临床试验。

已经对深海水（DSW）的降脂作用进行了研究，但临床证据仍远没有定论。因此，本研究旨在检查精制DSW（RDSW）对高胆固醇血症的影响。在这项随机，双盲，安慰剂对照试验中，将78名韩国受试者随机分为饮用RDSW 8周的RDSW组或安慰剂组。在第0、4和8周从所有受试者收集临床实验室信息。两组均显示总胆固醇（TC）显着降低，而仅RDSW组在研究期间显示低密度脂蛋白胆固醇（LDL-c）显着降低。两组的分层分析显示，中度高TC亚组的TC显着降低。然而，只有RDSW在高LDL-c亚组中表现出LDL-c的显着下降。另外，RDSW组脂蛋白（a）显着降低，而安慰剂组则没有。RDSW不会影响其他脂质分布，包括高密度脂蛋白胆固醇（HDL-c），甘油三酸酯，游离脂肪酸，载脂蛋白以及其他标记，包括炎症标记，血液学参数，血液和尿液化学成分以及生命体征。RDSW通过降低高胆固醇血症患者的TC和LDL-c改善其脂质谱，同时保持HDL-c的水平。其他标记，包括炎症标记，血液学参数，血液和尿液化学成分以及生命体征。RDSW通过降低高胆固醇血症患者的TC和LDL-c改善其脂质谱，同时保持HDL-c的水平。其他标记，包括炎症标记，血液学参数，血液和尿液化学成分以及生命体征。RDSW通过降低高胆固醇血症患者的TC和LDL-c改善其脂质谱，同时保持HDL-c的水平。