Second-Generation Dendrimers with Chondroitin Sulfate Type-E Disaccharides as Multivalent Ligands for Langerin.,Biomacromolecules

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Second-Generation Dendrimers with Chondroitin Sulfate Type-E Disaccharides as Multivalent Ligands for Langerin.
Biomacromolecules ( IF 5.5 ) Pub Date : 2020-06-11 , DOI: 10.1021/acs.biomac.0c00476
Pedro Domínguez-Rodríguez ₁ , Corinne Vivès ₂ , Michel Thepaut ₂ , Franck Fieschi ₂ , Pedro M Nieto ₁ , José L de Paz ₁ , Javier Rojo ₁

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Chondroitin sulfate type-E (CS-E) is a sulfated polysaccharide that shows several interesting biological activities, such as modulation of the neuronal growth factor signaling and its interaction with langerin, a C-type lectin with a crucial role in the immunological system. However, applications of CS-E are hampered by the typical heterogeneous structure of the natural polysaccharide. Well-defined, homogeneous CS-E analogues are highly demanded. Here, we report the synthesis of monodispersed, structurally well-defined second-generation glycodendrimers displaying up to 18 CS-E disaccharide units. These complex multivalent systems have a molecular weight and a number of disaccharide repeating units comparable with those of the natural polysaccharides. In addition, surface plasmon resonance experiments revealed a calcium-independent interaction between these glycodendrimers and langerin, in the micromolar range, highlighting the utility of these compounds as CS-E mimetics.

中文翻译：

硫酸软骨素E型二糖作为朗格琳多价配体的第二代树状聚合物。

E型硫酸软骨素（CS-E）是一种硫酸化的多糖，具有多种有趣的生物学活性，例如神经元生长因子信号传导的调节及其与Langerin（一种在免疫系统中起关键作用的C型凝集素）的相互作用。然而，CS-E的应用受到天然多糖的典型异质结构的阻碍。强烈要求定义清晰，同质的CS-E类似物。在这里，我们报告显示最多18个CS-E二糖单元的单分散，结构明确的第二代糖类树状大分子的合成。这些复杂的多价系统具有与天然多糖相当的分子量和许多二糖重复单元。此外，

更新日期：2020-07-13

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