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Validation of HPLC Method for Determination of Histamine in Human Immunoglobulin Formulations
Journal of AOAC INTERNATIONAL ( IF 1.6 ) Pub Date : 2020-06-08 , DOI: 10.1093/jaoacint/qsaa017
Michikazu Tanio 1 , Toru Nakamura 2 , Hideki Kusunoki 1 , Kyohei Ideguchi 2 , Kazuyuki Nakashima 2 , Isao Hamaguchi 1
Affiliation  

Histamine fixed-immunoglobulin formulations, which consisted of 0.15 µg of histamine dihydrochloride and 12 mg of human immunoglobulin in a vial, are used for anti-allergic treatments, and controlling the amounts of histamine in the formulations is essential to avoid histamine intoxication.

中文翻译:

高效液相色谱法测定人免疫球蛋白制剂中组胺的验证

组胺固定的免疫球蛋白制剂(由小瓶中的0.15 µg组胺二盐酸盐和12 mg人免疫球蛋白组成)用于抗过敏治疗,控制制剂中组胺的量对于避免组胺中毒至关重要。
更新日期:2020-06-08
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