Abstract

Toll-like receptor 2 (TLR2) plays a key role in innate immune response recognizing molecular patterns expressed by pathogens. rs111200466 is a TLR2 promoter insertion/deletion polymorphism with contradictory data about its role in human immunodeficiency virus type 1 (HIV-1) infection. We analyzed rs111200466 in HIV-1 disease progression and showed a correlation with a faster progression to the CD4⁺ < 200 cells/μL outcome for deletion allele carriers (Cox regression analysis: hazard ratio, 2.4 [95% confidence interval, 1.4–4]; P = .001). When naive patients with CD4⁺ < 200 cells/μL started antiretroviral treatment, rs111200466-deletion carriers showed a trend toward a slower, recovery rate (time required to reach CD4⁺ > 350 cells/μL; Cox P = .36). Our data suggest rs111200466 as a prognosis factor for HIV-1 disease progression.

中文翻译：

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Toll样受体2启动子-196至-174缺失会影响HIV感染过程中CD4的水平。

摘要

Toll样受体2（TLR2）在识别病原体表达的分子模式的先天免疫应答中起关键作用。rs111200466是TLR2启动子插入/缺失多态性，其在人类1型免疫缺陷病毒（HIV-1）感染中的作用相关数据相互矛盾。我们分析了rs111200466在HIV-1疾病中的进展，并显示与缺失等位基因携带者的CD4 ⁺ <200细胞/μL结果更快进展相关（Cox回归分析：危险比，2.4 [95％置信区间，1.4–4] ；P  = 0.001）。当幼稚的CD4 ⁺ <200细胞/μL的患者开始接受抗逆转录病毒治疗时，rs111200466-缺失载体显示出恢复速度较慢的趋势（达到CD4 ⁺所需的时间）> 350细胞/μL; Cox P  = 0.36）。我们的数据表明rs111200466是HIV-1疾病进展的预后因素。