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Polymeric Biomaterial Scaffolds for Tumoricidal Stem Cell Glioblastoma Therapy
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-06-11 , DOI: 10.1021/acsbiomaterials.0c00477 Kathryn M Moore 1 , Ananya B Murthy 2 , Elizabeth G Graham-Gurysh 2 , Shawn D Hingtgen 2 , Eric M Bachelder 2 , Kristy M Ainslie 1, 2, 3
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-06-11 , DOI: 10.1021/acsbiomaterials.0c00477 Kathryn M Moore 1 , Ananya B Murthy 2 , Elizabeth G Graham-Gurysh 2 , Shawn D Hingtgen 2 , Eric M Bachelder 2 , Kristy M Ainslie 1, 2, 3
Affiliation
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Glioblastoma (GBM) is the most common primary brain tumor and has a poor prognosis; as such, there is an urgent need to develop innovative new therapies. Tumoricidal stem cells are an emerging therapy that has the potential to combat limitations of traditional local and systemic chemotherapeutic strategies for GBM by providing a source for high, sustained concentrations of tumoricidal agents locally to the tumor. One major roadblock for tumoricidal stem cell therapy is that the persistence of tumoricidal stem cells injected as a cell suspension into the GBM surgical resection cavity is limited. Polymeric biomaterial scaffolds have been utilized to enhance the delivery of tumoricidal stem cells in the surgical resection cavity and extend their persistence in the brain, ultimately increasing their therapeutic efficacy against GBM. In this review, we examine three main scaffold categories explored for tumoricidal stem cell therapy: microcapsules, hydrogels, and electrospun scaffolds. Furthermore, considering the significant impact of surgery on the brain and recurrent GBM, we survey a brief history of orthotopic models of GBM surgical resection.
中文翻译：
用于杀肿瘤干细胞胶质母细胞瘤治疗的聚合物生物材料支架
胶质母细胞瘤（GBM）是最常见的原发性脑肿瘤，预后较差；因此，迫切需要开发创新的新疗法。杀肿瘤干细胞是一种新兴疗法，通过为肿瘤局部提供高、持续浓度的杀肿瘤药物来源，有可能克服 GBM 传统局部和全身化疗策略的局限性。杀肿瘤干细胞治疗的一个主要障碍是，以细胞悬液形式注射到 GBM 手术切除腔中的杀肿瘤干细胞的持久性是有限的。聚合物生物材料支架已被用来增强杀肿瘤干细胞在手术切除腔内的输送，并延长其在大脑中的持久性，最终提高其对 GBM 的治疗效果。在这篇综述中，我们研究了用于杀肿瘤干细胞治疗的三种主要支架类别：微胶囊、水凝胶和电纺支架。此外，考虑到手术对大脑和复发性 GBM 的显着影响，我们调查了 GBM 手术切除原位模型的简史。
更新日期：2020-07-13
中文翻译：
用于杀肿瘤干细胞胶质母细胞瘤治疗的聚合物生物材料支架
胶质母细胞瘤（GBM）是最常见的原发性脑肿瘤，预后较差；因此，迫切需要开发创新的新疗法。杀肿瘤干细胞是一种新兴疗法，通过为肿瘤局部提供高、持续浓度的杀肿瘤药物来源，有可能克服 GBM 传统局部和全身化疗策略的局限性。杀肿瘤干细胞治疗的一个主要障碍是，以细胞悬液形式注射到 GBM 手术切除腔中的杀肿瘤干细胞的持久性是有限的。聚合物生物材料支架已被用来增强杀肿瘤干细胞在手术切除腔内的输送，并延长其在大脑中的持久性，最终提高其对 GBM 的治疗效果。在这篇综述中，我们研究了用于杀肿瘤干细胞治疗的三种主要支架类别：微胶囊、水凝胶和电纺支架。此外，考虑到手术对大脑和复发性 GBM 的显着影响，我们调查了 GBM 手术切除原位模型的简史。
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