ABSTRACT

The purpose of this review is to highlight several areas of lncRNA biology and cancer that we hope will provide some new insights for future research. These include the relationship of lncRNAs and the epithelial to mesenchymal transition (EMT) with a focus on transcriptional and alternative splicing mechanisms and mRNA stability through miRNAs. In addition, we highlight the potential role of enhancer e-lncRNAs, the importance of transposable elements in lncRNA biology, and finally the emerging area of using antisense oligonucleotides (ASOs) and small molecules to target lncRNAs and their therapeutic implications.

中文翻译：

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长链非编码 RNA 的新转折：从移动元件到移动癌细胞。

摘要

本综述的目的是突出 lncRNA 生物学和癌症的几个领域，我们希望这些领域能为未来的研究提供一些新的见解。这些包括 lncRNA 和上皮间质转化 (EMT) 的关系，重点是转录和选择性剪接机制以及通过 miRNA 的 mRNA 稳定性。此外，我们强调了增强子 e-lncRNA 的潜在作用、转座因子在 lncRNA 生物学中的重要性，以及最后使用反义寡核苷酸 (ASO) 和小分子靶向 lncRNA 的新兴领域及其治疗意义。