Macroautophagy/autophagy was recently shown to regulate unconventional protein secretion through a process called secretory autophagy. How the secretory cargo selectively enters into the secretory autophagosome has been a central question. Our recent studies indicate that cargo translocation into the ER-Golgi intermediate compartment, a compartment contributing membranes to the forming autophagosome, acts as a mechanism for secretory cargo entry into the vesicle and may be an early step for secretory autophagy.

中文翻译：

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蛋白质易位到ERGIC中：分泌自噬的上游事件。

最近显示，巨自噬/自噬通过称为分泌自噬的过程调节非常规蛋白质的分泌。分泌货物如何选择性地进入分泌自噬体一直是一个核心问题。我们最近的研究表明，货物转运到ER-高尔基体中间隔室中，该隔室为形成的自噬小体贡献膜，是分泌性货物进入囊泡的机制，并且可能是分泌自噬的早期步骤。