The human endocannabinoid system (ECS) is a complex signalling network involved in many key physiological processes. The ECS includes the cannabinoid receptors, the endocannabinoid ligands, and the enzymes related to their synthesis and degradation. Other cannabinoids encompass the phytocannabinoids from Cannabis sativaL.(marijuana) and the synthetic cannabinoids. Alterations in the ECS are associated with different diseases, including inflammatory and immune-mediated disorders such as allergy. Allergy is a global health problem of increasing prevalence with high socio-economic impact. Different studies have convincingly demonstrated that cannabinoids play a role in allergy, but their actual contribution is still controversial. It has been shown that cannabinoids exert anti-inflammatory properties in the airways and the skin of allergic patients. Other studies reported that cannabinoids might exacerbate asthma and atopic dermatitis mainly depending on CB2-mediated signalling pathways. A better understanding of the molecular mechanisms involved in the mode of action of specific cannabinoids and cannabinoid receptors on relevant immune cells under different biological contexts might well contribute to the design of novel strategies for the prevention and treatment of allergic diseases. Future research in this promising emerging field in the context of allergy is warranted for the upcoming years.
Int Arch Allergy Immunol

中文翻译：

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大麻素在变应性疾病中的作用：国际变态反应堆（CIA）2020年更新。

人体内大麻素系统（ECS）是一个复杂的信号网络，涉及许多关键的生理过程。ECS包括大麻素受体，内源性大麻素配体以及与其合成和降解相关的酶。其他大麻素包括来自大麻的植物大麻素。（大麻）和合成大麻素。ECS的改变与各种疾病有关，包括炎症和免疫介导的疾病，例如变态反应。变态反应是全球性的健康问题，其流行率不断提高，并具有很高的社会经济影响。不同的研究令人信服地表明，大麻素在过敏中起作用，但其实际贡献仍存在争议。已经显示，大麻素在变态反应患者的气道和皮肤中发挥抗炎作用。其他研究报道，大麻素可能加剧哮喘和特应性皮炎，主要取决于CB2介导的信号通路。更好地了解特定大麻素和大麻素受体在不同生物学环境下对相关免疫细胞的作用方式所涉及的分子机制，可能会有助于设计预防和治疗变应性疾病的新策略。在过敏的背景下，有希望在这个有前途的新兴领域中进行未来的研究是值得的。
Int Arch过敏免疫