当前位置: X-MOL 学术Synthesis › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
P(OEt)3-Mediated Formal S–H Insertion: Reductive Couplings of Isatins with Thiols to Generate 3-Sulfenylated Oxindoles
Synthesis ( IF 2.2 ) Pub Date : 2020-06-10 , DOI: 10.1055/s-0040-1707147
Dulin Kong 1 , Mingshu Wu 2 , Tiao Huang 2 , Li Liu 2 , Qinghe Wang 2
Affiliation  


Abstract

A new P(OEt)3-mediated formal S–H bond-insertion reaction of isatins into thiols for the synthesis of valuable 3-sulfenylation oxindoles has been developed. This approach takes advantage of the unique reactivity of Kukhtin–Ramirez adducts to allow direct reductive S–H functionalization with commercially available and bench-stable starting materials.



中文翻译:

P(OEt)3介导的正规S–H插入:靛红与硫醇的还原偶联,生成3-亚磺酰基化的吲哚。


摘要

已开发出一种新的P(OEt)3介导的将靛红转化为巯基的正式H-H键插入反应,以合成有价值的3-磺酰基化吲哚。这种方法利用了Kukhtin-Ramirez加合物的独特反应性,可以使用市售的和稳定的起始原料直接还原S-H官能化。

更新日期:2020-06-10
down
wechat
bug