Abstract

A new P(OEt)₃-mediated formal S–H bond-insertion reaction of isatins into thiols for the synthesis of valuable 3-sulfenylation oxindoles has been developed. This approach takes advantage of the unique reactivity of Kukhtin–Ramirez adducts to allow direct reductive S–H functionalization with commercially available and bench-stable starting materials.

中文翻译：

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P（OEt）3介导的正规S–H插入：靛红与硫醇的还原偶联，生成3-亚磺酰基化的吲哚。

摘要

已开发出一种新的P（OEt）₃介导的将靛红转化为巯基的正式H-H键插入反应，以合成有价值的3-磺酰基化吲哚。这种方法利用了Kukhtin-Ramirez加合物的独特反应性，可以使用市售的和稳定的起始原料直接还原S-H官能化。