Interventional regenerative medicine (IRM) uses image-guided, minimally invasive procedures for the targeted delivery of stem cell–based therapies to regenerate, replace, or repair damaged organs. Although many cellular therapies have shown promise in the preclinical setting, clinical results have been suboptimal. Most intravenously delivered cells become trapped in the lungs and reticuloendothelial system, resulting in little therapy reaching target tissues. IRM aims to increase the efficacy of cell-based therapies by locoregional stem cell delivery via endovascular, endoluminal, or direct injection into tissues. This review highlights routes of delivery, disease states, and mechanisms of action involved in the targeted delivery of stem cells.

介入再生医学 (IRM) 使用图像引导的微创手术来有针对性地提供基于干细胞的疗法，以再生、替换或修复受损的器官。尽管许多细胞疗法在临床前环境中显示出希望，但临床结果并不理想。大多数静脉输送的细胞被困在肺部和网状内皮系统中，导致几乎没有治疗到达靶组织。 IRM 旨在通过血管内、腔内或直接注射到组织中进行局部干细胞递送，从而提高基于细胞的疗法的功效。这篇综述重点介绍了干细胞靶向递送所涉及的递送途径、疾病状态和作用机制。