This special issue of evolutionary applications focused on the evolution of cancer has provided a wealth of different viewpoints and results from leaders in the field. Together, these papers emphasize the importance of a broad perspective in order to understand why we and other animals get cancer, how it evolves within an individual, and what we can do about it. We can no longer take reductionist approaches that consider only the cancer cells and their genes. Instead, we need to understand how millions of years of evolution have guided strategies that shape cancer risk, why cancer risk varies across different animals, how cancer risk can vary in a population and be influenced by ecology (and influence this ecology), and of course how cancers evolve within us and the evolutionarily informed strategies to counter their impact. My goal here will be to “bring it all home,” providing a refresher of lessons learned with added kibitzing.

中文翻译：

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关于癌症和进化的特刊：经验教训。


本期进化应用特刊聚焦于癌症的进化，提供了该领域领导者的大量不同观点和结果。这些论文共同强调了广泛视角的重要性，以了解我们和其他动物为什么会患上癌症、癌症在个体中如何演变以及我们可以采取哪些措施。我们不能再采取只考虑癌细胞及其基因的还原论方法。相反，我们需要了解数百万年的进化如何指导塑造癌症风险的策略，为什么不同动物的癌症风险不同，癌症风险如何在人群中变化以及如何受到生态的影响（并影响这种生态），以及课程介绍癌症如何在我们体内进化以及对抗其影响的进化策略。我在这里的目标是“把所有的东西带回家”，通过增加一些有趣的内容来回顾所学到的经验教训。