It is plausible that apolipoprotein C3 (APOC3), patatin‐like phospholipase domain containing 3 (PNPLA3), and transmembrane 6 superfamily member 2 (TM6SF2) polymorphisms may affect predisposition of nonalcoholic fatty liver disease (NAFLD), but the results of so far published studies remain controversial. The authors conducted this meta‐analysis to clarify relationships between APOC3/PNPLA3/TM6SF2 polymorphisms and predisposition of NAFLD by pooling the findings of eligible studies. A comprehensive search of PubMed, Embase, Web of Science, and CNKI was endorsed by the authors to identify already published studies. Forty‐nine studies were found to be eligible for meta‐analyses. The pooled meta‐analyses results showed that genotypic frequencies of APOC3 rs2854116, PNPLA3 rs738409, and TM6SF2 rs58542926 polymorphisms among patients and controls differed significantly. Moreover, genotypic frequencies of PNPLA3 rs738409 and TM6SF2 rs58542926 polymorphisms among patients and controls from both Caucasians and Asians also differed significantly. But However, no such differences in genotypic frequencies were observed for the APOC3 rs2854117 polymorphism. This meta‐analysis suggested that APOC3 rs2854116, PNPLA3 rs738409, and TM6SF2 rs58542926 polymorphisms might affect predisposition of NAFLD.

中文翻译：

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APOC3 rs2854116 、PNPLA3 rs738409 和 TM6SF2 rs58542926 多态性可能影响 NAFLD 的易感性：荟萃分析

载脂蛋白 C3 (APOC3)、含有 3 的 patatin 样磷脂酶结构域 (PNPLA3) 和跨膜 6 超家族成员 2 (TM6SF2) 多态性可能影响非酒精性脂肪性肝病 (NAFLD) 的易感性是合理的，但迄今为止发表的结果研究仍然存在争议。作者通过汇总符合条件的研究结果，进行了这项荟萃分析，以阐明 APOC3/PNPLA3/TM6SF2 多态性与 NAFLD 易感性之间的关系。作者同意对 PubMed、Embase、Web of Science 和 CNKI 进行全面搜索，以识别已发表的研究。发现 49 项研究符合荟萃分析的条件。汇总的荟萃分析结果显示 APOC3 rs2854116、PNPLA3 rs738409、和 TM6SF2 rs58542926 多态性在患者和对照之间存在显着差异。此外，白种人和亚洲人的患者和对照的 PNPLA3 rs738409 和 TM6SF2 rs58542926 多态性的基因型频率也有显着差异。但是，对于 APOC3 rs2854117 多态性，没有观察到基因型频率的这种差异。该荟萃分析表明 APOC3 rs2854116、PNPLA3 rs738409 和 TM6SF2 rs58542926 多态性可能影响 NAFLD 的易感性。