Emotion regulation difficulties precipitate and exacerbate acute mood symptoms in individuals with bipolar disorder (BD), and contribute to suicidal behavior. However, few studies have examined regional brain responses in explicit emotion regulation during acute BD mood states, or hopelessness, a major suicide risk factor. We assessed brain responses during explicit emotion regulation, and their relationship with hopelessness, in acutely symptomatic and euthymic individuals with BD.

中文翻译：

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额叶皮层在情绪调节和双相情感障碍绝望中的功能改变

情绪调节困难会加速和加剧双相情感障碍 (BD) 患者的急性情绪症状，并导致自杀行为。然而，很少有研究检查在急性 BD 情绪状态或绝望（主要自杀风险因素）期间显性情绪调节中的区域大脑反应。我们评估了症状明显且情绪正常的 BD 患者在明确情绪调节期间的大脑反应，以及它们与绝望的关系。