Rapid Quantification of isoflurane in anesthetic nanoemulsions using Attenuated Total Reflectance Fourier Transform Infrared spectroscopy (ATR-FTIR),Vibrational Spectroscopy

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Rapid Quantification of isoflurane in anesthetic nanoemulsions using Attenuated Total Reflectance Fourier Transform Infrared spectroscopy (ATR-FTIR)
Vibrational Spectroscopy ( IF 2.7 ) Pub Date : 2020-07-01 , DOI: 10.1016/j.vibspec.2020.103095
Mohammad Hossein Tootoonchi , Ryan Bardsley , Thomai Panagiotou , Robert J. Fisher , Ernesto A. Pretto , Christopher A. Fraker

Abstract There is increased research into pharmaceutical nanoemulsions where the timing of quantification of active components can dictate continuous manufacturing production cost and consistency. The goal of this study was development of a rapid quantification method for isoflurane nanoemulsions using Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR). Isoflurane was quantified by ATR-FTIR and High-Performance Liquid Chromatography (HPLC). Correlation and agreement between methods was determined to validate the ATR-FTIR procedure. Evaporation rate studies from the nanoemulsions and pure isoflurane were performed. ATR-FTIR values were in agreement and correlated with (HPLC) measurements (calculated Pearson R of 0.99; 99 % confidence interval; P

中文翻译：

使用衰减全反射傅立叶变换红外光谱 (ATR-FTIR) 快速定量麻醉纳米乳剂中的异氟醚

摘要对药物纳米乳剂的研究越来越多，其中活性成分的定量时间可以决定连续制造的生产成本和一致性。本研究的目标是开发一种使用衰减全反射傅立叶变换红外光谱 (ATR-FTIR) 的异氟醚纳米乳剂的快速定量方法。异氟醚通过 ATR-FTIR 和高效液相色谱 (HPLC) 进行定量。确定方法之间的相关性和一致性以验证 ATR-FTIR 程序。进行了纳米乳剂和纯异氟醚的蒸发率研究。ATR-FTIR 值一致并与 (HPLC) 测量值相关（计算得出的 Pearson R 为 0.99；99% 置信区间；P

更新日期：2020-07-01

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