Prenatal cocaine exposure (PCE) has rarely been examined as a predictor of substance use during late adolescence, and few studies have examined both the initiation of substance use and current substance use as outcomes. The present longitudinal study examined PCE, other prenatal exposures, and psychosocial risk factors for their association with substance use in mid to late adolescence. Adolescents (n = 150) followed since birth reported on their use of alcohol, cigarette, and cannabis every 6 months from age 15.0 to 17.5 using a computer-assisted self-administration version of the Youth Risk Behavior Survey. PCE did not predict substance use in a series of growth curve analyses. Several psychosocial risk factors were associated with adolescents' substance use. Having friends who use substances predicted past month cigarette and cannabis use as well as initiation of alcohol and cannabis use, while depressive symptoms predicted initiation of alcohol, cigarette, and cannabis use. The current findings suggest that more proximal psychosocial factors may play a greater role in adolescent substance use than prenatal substance exposure.

产前可卡因暴露 (PCE) 很少被研究作为青春期后期物质使用的预测指标，并且很少有研究将物质使用的开始和当前的物质使用作为结果进行检查。本纵向研究检查了 PCE、其他产前暴露和心理社会风险因素与青春期中后期物质使用的关联。青少年 ( n = 150) 自出生以来，每 6 个月使用计算机辅助自我管理版本的青年风险行为调查报告他们使用酒精、香烟和大麻的情况，从 15.0 岁到 17.5 岁。PCE 并未在一系列增长曲线分析中预测物质使用。一些社会心理风险因素与青少年的物质使用有关。使用物质的朋友预测上个月使用香烟和大麻以及开始使用酒精和大麻，而抑郁症状预测开始使用酒精、香烟和大麻。目前的研究结果表明，与产前物质暴露相比，更接近的心理社会因素可能在青少年物质使用中发挥更大的作用。