Control of protein synthesis (mRNA translation) is essential for proper brain development and function. Perturbations to the mechanisms governing mRNA translation have repeatedly been shown to constitute a neurodegenerative, neuropsychiatric, and neurodevelopmental disorder risk factor. Developing effective therapeutics for brain disorders will require a better understanding of the molecular mechanisms underlying the control of protein synthesis in brain function. Studies using transgenic animal models have been invaluable towards this end, providing exciting new insights into the genetic basis of brain disorders with hopeful prospects for new and effective treatment options.

蛋白质合成的控制（mRNA翻译）对于大脑的正常发育和功能至关重要。反复证明，对控制mRNA翻译的机制的干扰构成了神经变性，神经精神病学和神经发育障碍的危险因素。开发针对脑部疾病的有效疗法将需要更好地了解控制脑功能中蛋白质合成的分子机制。为此目的，使用转基因动物模型的研究具有无可估量的价值，它为脑部疾病的遗传基础提供了令人振奋的新见解，并为新的有效治疗选择带来了希望。