Resting state signal latency assesses the propagation of intrinsic activations and estimates anti-epileptic effect of levetiracetam in Rolandic epilepsy.,Brain Research Bulletin

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Resting state signal latency assesses the propagation of intrinsic activations and estimates anti-epileptic effect of levetiracetam in Rolandic epilepsy.
Brain Research Bulletin ( IF 3.8 ) Pub Date : 2020-06-11 , DOI: 10.1016/j.brainresbull.2020.05.016
Qiang Xu ₁ , Zheng Hu ₂ , Fang Yang ₃ , Boris C Bernhardt ₄ , Qirui Zhang ₅ , Steven M Stufflebeaskm ₆ , Zhiqiang Zhang ₇ , Guangming Lu ₈

Affiliation

Department of Medical Imaging, Jinling Hospital, Medical school of Nanjing University, Nanjing, China; College Of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, China.
Department of Neurology, Nanjing Children's Hospital, Nanjing 210029, China.
Department of Neurology, Jinling Hospital, Medical school of Nanjing University, Nanjing, China.
Multimodal Imaging and Connectome Analysis Laboratory, Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada.
Department of Medical Imaging, Jinling Hospital, Medical school of Nanjing University, Nanjing, China.
Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Department of Medical Imaging, Jinling Hospital, Medical school of Nanjing University, Nanjing, China; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA; State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, China.
Department of Medical Imaging, Jinling Hospital, Medical school of Nanjing University, Nanjing, China; College Of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, China; State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, China.

Purpose

We assessed the potential of resting-state fMRI lag analysis (RSLA) in detecting epileptic activation and in estimating anti-epileptic effects of Levetiracetam (LEV) in Rolandic epilepsy.

Methods

Forty-three children with Rolandic epilepsy underwent simultaneous EEG-fMRI. They were grouped into LEV vs drug-naïve groups according to their medication, and into patients who showed or did not show central-temporal spike (CTS) discharges during scans. We calculated the lag structure of rs-fMRI for all patients and assessed interactions with drug (LEV vs. drug-naïve) and CTS status (CTS vs. no-CTS). We furthermore assessed correlations between lag values and number of CTS and medication conditions.

Results

RSLA analysis indicated earlier intrinsic activations in bilateral Rolandic areas when CTS occurred. More frequent epileptic discharges were correlated with earlier intrinsic activations (r=-0.46, p = 0.03 left Rolandic). Patients with LEV therapy, on the other hand, displayed delayed intrinsic activity in Rolandic areas compared to drug-naïve patients

Conclusion

Our RSLA analysis indicated an association between centro-temporal spikes and earlier hemodynamic activations in epileptogenic regions in Rolandic epilepsy, which were counteracted by LEV treatment. As it allows for the mapping of propagation features of intrinsic activity and drug-effects, our findings suggest potential of lag based analyses in detecting focus localization and estimating treatment effects.

中文翻译：

静息状态信号延迟评估内在激活的传播并估计左乙拉西坦在 Rolandic 癫痫中的抗癫痫作用。

目的

我们评估了静息态 fMRI 滞后分析 (RSLA) 在检测癫痫激活和估计左乙拉西坦 (LEV) 在 Rolandic 癫痫中的抗癫痫作用方面的潜力。

方法

43 名患有 Rolandic 癫痫的儿童同时接受了 EEG-fMRI。根据他们的药物治疗，将他们分为 LEV 组和未用药组，以及在扫描过程中显示或未显示中央时间尖峰 (CTS) 放电的患者。我们计算了所有患者的 rs-fMRI 的滞后结构，并评估了与药物的相互作用（LEV与未使用药物）和 CTS 状态（CTS与非 CTS）。我们进一步评估了滞后值与 CTS 数量和药物治疗条件之间的相关性。