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The phylogenetic distribution of the glutaminyl-tRNA synthetase and Glu-tRNAGln amidotransferase in the fundamental lineages would imply that the ancestor of archaea, that of eukaryotes and LUCA were progenotes.
Biosystems ( IF 2.0 ) Pub Date : 2020-06-11 , DOI: 10.1016/j.biosystems.2020.104174
Massimo Di Giulio 1
Affiliation  

The function of the glutaminyl-tRNA synthetase and Glu-tRNAGln amidotransferase might be related to the origin of the genetic code because, for example, glutaminyl-tRNA synthetase catalyses the fundamental reaction that makes the genetic code. If the evolutionary stage of the origin of these two enzymes could be unambiguously identified, then the genetic code should still have been originating at that particular evolutionary stage because the fundamental reaction that makes the code itself was still evidently evolving. This would result in that particular evolutionary moment being attributed to the evolutionary stage of the progenote because it would have a relationship between the genotype and the phenotype not yet fully realized because the genetic code was precisely still originating. I then analyzed the distribution of the glutaminyl-tRNA synthetase and Glu-tRNAGln aminodotrasferase in the main phyletic lineages. Since in some cases the origin of these two enzymes can be related to the evolutionary stages of ancestors of archaea and eukaryotes, this would indicate these ancestors as progenotes because at that evolutionary moment the genetic code was evidently still evolving, thus realizing the definition of progenote. The conclusion that the ancestor of archaea and that of eukaryotes were progenotes would imply that even the last universal common ancestor (LUCA) was a progenote because it appeared, on the tree of life, temporally before these ancestors.



中文翻译:

谷氨酰胺-tRNA合成酶和Glu-tRNAGln酰胺转移酶在基本谱系中的系统发育分布将暗示古细菌的祖先,真核生物和LUCA是祖先。

谷氨酰胺-tRNA合成酶和Glu-tRNA Gln的功能酰胺基转移酶可能与遗传密码的起源有关,因为例如谷氨酰胺-tRNA合成酶催化了构成遗传密码的基本反应。如果可以明确地确定这两种酶的起源的进化阶段,那么遗传密码应该仍然起源于那个特定的进化阶段,因为构成密码本身的基本反应仍在明显地发展。这将导致该特定的进化时刻被归因于该祖先的进化阶段,因为它可能在基因型和表型之间具有一种尚未完全实现的关系,因为遗传密码恰好仍在起源。然后,我分析了谷氨酰胺-tRNA合成酶和Glu-tRNA Gln的分布氨基转移酶的主要系统谱系。由于在某些情况下,这两种酶的起源可能与古细菌和真核生物的祖先的进化阶段有关,因此这将表明这些祖先是祖先,因为在那个进化时刻,遗传密码显然仍在进化,因此实现了祖先的定义。 。结论:古细菌和真核生物的祖先是祖先,这意味着即使最后一个通用祖先(LUCA)也是祖先,因为它在生命树上暂时出现在这些祖先之前。

更新日期:2020-06-11
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