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C-peptide corrects hepatocellular dysfunction in a rat model of type 1 diabetes.
Journal of Physiology and Biochemistry ( IF 3.7 ) Pub Date : 2020-06-11 , DOI: 10.1007/s13105-020-00748-y
Heba A Abdel-Hamid 1 , Elshymaa A Abdel-Hakeem 1 , Nagwa M Zenhom 2 , Nisreen D M Toni 3
Affiliation  

C-peptide is gaining much interest recently due to its well-documented beneficial effects on multiple organ dysfunction induced by diabetes. Our study was designed to investigate the effect of C-peptide on hepatocellular dysfunction in diabetic rats. Wistar male rats were separated into four groups: control, diabetic, diabetic + insulin, and diabetic + C-peptide. Serum levels of glucose, insulin, and liver biomarkers were assessed. Liver sections were collected for histopathological examination and immuno-histochemical assessment of tumor necrosis factor alpha (TNF-α). Oxidative stress markers and gene expression of inducible nitric oxide synthase (iNOS), transforming growth factor beta 1 (TGF-β1), and glucose-6-phosphatase (G6Pase) were also measured in liver tissues. C-peptide administration prevented hepatic dysfunction induced by diabetes to a similar extent as that of insulin which was confirmed microscopically. We concluded that C-peptide could be used as an alternative therapy to insulin to correct hepatocellular dysfunction associated with type 1 diabetes mellitus (T1DM).

中文翻译:

C肽可纠正1型糖尿病大鼠模型中的肝细胞功能障碍。

由于C肽对糖尿病引起的多器官功能障碍的有益作用,最近C肽引起了人们极大的兴趣。我们的研究旨在研究C肽对糖尿病大鼠肝细胞功能障碍的影响。将Wistar雄性大鼠分为四组:对照组,糖尿病,糖尿病+胰岛素和糖尿病+ C肽。评估血清葡萄糖,胰岛素和肝脏生物标志物的水平。收集肝切片用于肿瘤坏死因子α(TNF-α)的组织病理学检查和免疫组织化学评估。还测量了肝脏组织中氧化应激标志物和诱导型一氧化氮合酶(iNOS),转化生长因子β1(TGF-β1)和葡萄糖-6-磷酸酶(G6Pase)的基因表达。给予C肽可预防糖尿病引起的肝功能异常,其程度与经显微镜证实的胰岛素相似。我们得出的结论是,C肽可用作胰岛素的替代疗法,以纠正与1型糖尿病(T1DM)相关的肝细胞功能障碍。
更新日期:2020-06-11
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