Herein, we report a novel method for the synthesis of Prussian blue/PB containing polymeric hybrid nanoparticles. This method employs poly(4-vinylpyridine)/P4VP stabilized polystyrene/PS nanoparticles as a template to define the position of Prussian blue product. In the first step, the templates of P4VP-stabilized polystyrene polymer nanoparticle were prepared by dispersion polymerization of styrene in methanol/water in the presence of macro-P4VP chain transfer agents. With the addition of sodium pentacyanoammineferroate(II) hydrate/[Fe(CN)₅NH₃]³⁻ into dispersion, pyridyl moieties in P4VP in polymeric nanoparticles could react with [Fe(CN)₅NH₃]³⁻ through a ligand exchange reaction. Subsequent metal coordination polymerization of Fe³⁺ with ferrate confined within the surface of the nanoparticles led to the generation of monodispersed PB coated polymeric nanoparticles. The nanoparticles were characterized and confirmed by various modern techniques such as FT-IR, UV–Vis, TGA, XPS, TEM, SEM and AFM. The UV–Vis, FT-IR, TGA and XPS studies suggested Prussian blue was successfully coordinated with P4VP-PS polymers template according to our experimental design. The morphology studies indicated that spherical nanoparticles were obtained. In particular, the EDX mapping results clearly show that the iron element is evenly distributed on the nanoparticles. In addition, two parameters, including the amount of initiator and the amount of iron in the system, have important effects on the particle size and distribution. This experimental system we designed has great potential for the synthesis of metal containing polymeric nanoparticles with other compositions and morphologies, which offers many possibilities worthy of further exploration.

在这里，我们报告了一种新的合成普鲁士蓝/ PB的聚合物杂化纳米粒子的方法。该方法采用聚（4-乙烯基吡啶）/ P4VP稳定的聚苯乙烯/ PS纳米颗粒作为模板来定义普鲁士蓝产物的位置。在第一步中，通过在大P4VP链转移剂的存在下，将苯乙烯在甲醇/水中的分散聚合反应来制备P4VP稳定的聚苯乙烯聚合物纳米颗粒的模板。通过将五水合氨基亚氨基亚铁酸钠水合物/ [Fe（CN）₅ NH ₃ ] ^3-添加到分散体中，聚合物纳米颗粒中P4VP中的吡啶基部分可与[Fe（CN）₅ NH ₃ ] ^3-发生反应。通过配体交换反应。随后的Fe ^3+的金属配位聚合高铁酸盐被限制在纳米颗粒的表面内导致单分散的PB涂覆的聚合物纳米颗粒的产生。通过多种现代技术，例如FT-IR，UV-Vis，TGA，XPS，TEM，SEM和AFM对纳米颗粒进行了表征和确认。UV-Vis，FT-IR，TGA和XPS研究表明，根据我们的实验设计，普鲁士蓝已成功与P4VP-PS聚合物模板配合使用。形态研究表明获得了球形纳米颗粒。特别地，EDX作图结果清楚地表明铁元素均匀地分布在纳米颗粒上。此外，系统中引发剂的量和铁的量这两个参数对粒径和分布有重要影响。