Background Urinary dysfunction is a common symptom during the course of multiple sclerosis (MS). Long-term follow-up of the natural history of bladder dysfunction in MS has been seldom addressed. Objective To identify the type and the course of voiding dysfunction in MS patients in relation to the urodynamic changes of the lower urinary tract (LUT) Subjects and methods An observational prospective study including 120 MS patients with urinary dysfunction rated by the American Urological Association (AUA) symptoms questionnaire and assessed by urodynamic studies and followed for 1 year. Results Irritative symptoms were the most frequently encountered symptoms (90%), whereas overactive bladder was recorded by urodynamic studies in 35% of subjects. Urinary symptoms severity score was higher in patients with initial urodynamic abnormalities by the end of the 1-year follow-up period ( P < 0.001). A statistically significant relationship was found between urinary symptoms severity score and each of expanded disability status scale (EDSS) and urodynamic pattern of abnormalities ( P < 0.01). Conclusion Irritative symptoms and overactive bladder seem to be the most frequent urinary dysfunction in MS patients. Urinary symptoms are related to the degree of disability. The initial urodynamic abnormalities are associated with worse urinary dysfunction outcome after 1 year.

中文翻译：

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多发性硬化症的膀胱和尿动力学变化

背景泌尿功能障碍是多发性硬化症 (MS) 病程中的常见症状。很少涉及 MS 膀胱功能障碍自然病程的长期随访。目的 确定与下尿路 (LUT) 尿动力学变化相关的 MS 患者排尿功能障碍的类型和病程 受试者和方法 一项观察性前瞻性研究，包括 120 名美国泌尿学协会 (AUA) 评定的尿功能障碍 MS 患者) 症状问卷调查并通过尿动力学研究进行评估，并随访 1 年。结果 刺激症状是最常见的症状 (90%)，而尿动力学研究记录了 35% 的受试者膀胱过度活动症。到 1 年随访期结束时，初始尿动力学异常患者的泌尿症状严重程度评分较高（ P < 0.001）。泌尿系统症状严重程度评分与扩展残疾状态量表（EDSS）和尿动力学异常模式之间存在统计学显着关系（ P < 0.01）。结论 刺激症状和膀胱过度活动症似乎是 MS 患者最常见的泌尿功能障碍。排尿症状与残疾程度有关。最初的尿动力学异常与 1 年后更严重的泌尿功能障碍结果相关。泌尿系统症状严重程度评分与扩展残疾状态量表（EDSS）和尿动力学异常模式之间存在统计学显着关系（ P < 0.01）。结论 刺激症状和膀胱过度活动症似乎是 MS 患者最常见的泌尿功能障碍。排尿症状与残疾程度有关。最初的尿动力学异常与 1 年后更严重的泌尿功能障碍结果相关。泌尿系统症状严重程度评分与扩展残疾状态量表（EDSS）和尿动力学异常模式之间存在统计学显着关系（ P < 0.01）。结论 刺激症状和膀胱过度活动症似乎是 MS 患者最常见的泌尿功能障碍。排尿症状与残疾程度有关。最初的尿动力学异常与 1 年后更严重的泌尿功能障碍结果相关。