Background High levels of inflammatory markers such as C-reactive protein (CRP) and interleukin (IL)-6 are associated with worse outcome after ischemic stroke. Objectives To study whether the level of IL-6 following ischemic stroke is related to the severity of stroke, infarct volume, stroke subtype, and its impact on stroke outcome. Materials and methods A total of 90 patients of acute ischemic stroke were enrolled with calculation of infarct volume in MRI brain, and serum IL-6 samples were obtained within 24 h and also after 3 months from stroke onset. NIHSS and MRS were done at stroke onset and after 3 months. Results The mean value of IL-6 was higher among patients with small vessel occlusion (8.47 pg/ml) with a significant positive correlation between IL-6 and National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (MRS) after 3 months. IL-6 was significantly higher in patients with recurrence with a cutoff IL-6 value above which recurrence is anticipated which is 7.75 pg/ml. Conclusion Our study concluded that inflammation has an important role in the pathogenesis of acute ischemic stroke particularly small vessel occlusion and it provided evidence that IL-6 contributes to the determination of clinical outcome of acute ischemic stroke and prediction of recurrence.

中文翻译：

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白细胞介素6在缺血性卒中结局中的作用

背景 高水平的炎症标志物如 C 反应蛋白 (CRP) 和白细胞介素 (IL)-6 与缺血性卒中后较差的预后相关。目的 研究缺血性卒中后 IL-6 水平是否与卒中严重程度、梗死体积、卒中亚型及其对卒中结局的影响有关。材料与方法 共纳入 90 例急性缺血性卒中患者，计算 MRI 脑梗死体积，并在卒中发生后 24 小时内和 3 个月后采集血清 IL-6 样本。NIHSS 和 MRS 在卒中发作时和 3 个月后进行。结果 小血管闭塞患者 IL-6 的平均值较高 (8. 47 pg/ml)，3 个月后 IL-6 与美国国立卫生研究院卒中量表 (NIHSS) 和改良 Rankin 量表 (MRS) 之间呈显着正相关。IL-6 在复发患者中显着更高，IL-6 临界值高于该值，预期复发为 7.75 pg/ml。结论 我们的研究得出结论，炎症在急性缺血性卒中特别是小血管闭塞的发病机制中具有重要作用，并且提供了证据表明 IL-6 有助于确定急性缺血性卒中的临床结果和预测复发。