Pleurodesis is defined as symphysis between two layers of pleura to prevent recurrence of effusion, and it is the best available treatment for recurrent effusions of incurable malignancies. An ideal agent must be highly effective, safe, inexpensive, and readily available which is yet to be identified. The aim of this study was to assess our results of medical pleurodesis, using 3 different chemical agents: bleomycin ampoules, doxycycline capsules, povidone–iodine solution, through two different routes, chest tube and small bore indwelling catheter. Over a period of 5 years, 104 patients with malignant recurrent pleural effusion underwent pleurodesis at our university hospital, using 3 different agents and two routes of delivery. Fifty patients were male, patients’ age ranged from 22 to 74 years (57.55 ± 9.02). Fifty-nine patients (56.7%) had right-sided effusion, 61 patients (58.7%) had massive effusion. All patients were dyspneic. The rout of effusion drainage and sclerosing agent instillation was chest tube in 64 patients (61.5%) and small indwelling catheter in 40 patients. Forty-three patients received bleomycin, 36 patients received doxycycline, and 25 patients received povidone–iodine. The total success rate was 78.8%. Pleurodesis is a safe acceptable palliative procedure for malignant pleural effusion with not yet definite ideal agent or rout. Hence, the availability and the expense of agent are important.

中文翻译：

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化学胸膜固定术治疗恶性胸腔积液：哪种药物最合适？

胸膜固定术被定义为两层胸膜之间的共生体，以防止积液复发，它是可治愈的恶性肿瘤反复积液的最佳可用治疗方法。理想的试剂必须高效，安全，廉价且易于获得，尚待确定。这项研究的目的是通过三种不同的途径（胸管和小口径留置导管）使用三种不同的化学试剂评估博莱多病的医学结果：博来霉素安瓿，强力霉素胶囊，聚维酮碘溶液。在5年的时间里，我们的大学医院采用3种不同的药物和两种分娩途径对104例恶性复发性胸腔积液患者进行了胸膜固定术。五十名患者为男性，患者年龄为22至74岁（57.55±9.02）。59名患者（56。右侧积液占7％），大量积液占61例（58.7％）。所有患者均为呼吸困难。积液引流和硬化剂滴注的发生率是64例患者（61.5％）的胸管和40例患者的小留置导管。43例患者接受了博来霉素，36例患者接受了强力霉素，25例患者接受了聚维酮碘。总成功率为78.8％。胸膜固定术是恶性胸腔积液的安全可接受的姑息治疗方法，尚无理想的理想药物或溃烂。因此，代理的可用性和费用很重要。43例患者接受了博来霉素，36例患者接受了强力霉素，25例患者接受了聚维酮碘。总成功率为78.8％。胸膜固定术是恶性胸腔积液的安全可接受的姑息治疗方法，尚无理想的理想药物或溃烂。因此，代理的可用性和费用很重要。43例患者接受了博来霉素，36例患者接受了强力霉素，25例患者接受了聚维酮碘。总成功率为78.8％。胸膜固定术是恶性胸腔积液的安全可接受的姑息治疗方法，尚无理想的理想药物或溃烂。因此，代理的可用性和费用很重要。