Thyme has been used for centuries in southeastern Morocco to treat a wide range of diseases such as inflammation disorders. The aim of the current study is to examine and to compare in vitro the anti-inflammatory, antioxidant, and anticoagulant activities of three thyme species grown in southeastern Morocco. Data showed that all studied species possess an important antioxidant activity: Thymus atlanticus (IC50 = 16.59 μg/mL), Thymus zygis (IC50 = 15.43 μg/mL), and Thymus satureioides (IC50 = 14.65 μg/mL). Concerning the anti-inflammatory activity, the highest effect was depicted in Thymus atlanticus followed by Thymus zygis and Thymus satureioides. With regard to the anticoagulant activity, the aqueous extract of these species prolongs activated partial thromboplastin time, prothrombin time, and thrombin time significantly (p < 0.05) in a dose-dependent manner. Our results provide evidence that thymus extract exhibits marked antioxidant, anticoagulant, and anti-inflammatory effects, thus justifying the popular uses of these plants to treat some inflammatory and cardiovascular illnesses.

中文翻译：

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摩洛哥东南部生长的三种胸腺物种的抗氧化，抗炎和抗凝活性

百里香已在摩洛哥东南部使用了几个世纪，用于治疗各种疾病，例如炎症。本研究的目的是检查和比较摩洛哥东南部生长的三种百里香种类的抗炎，抗氧化和抗凝血活性。数据显示，所有研究的物种均具有重要的抗氧化活性：胸腺（IC50 = 16.59μg/ mL），百里香合子（IC50 = 15.43μg/ mL）和胸腺（IC50 = 14.65μg/ mL）。关于抗炎活性，在胸腺中表现出最高的效果，其次是百里香合子和胸腺。关于抗凝活性，这些种类的水提物显着延长了活化的部分凝血活酶时间，凝血酶原时间和凝血酶时间（p <0。05）剂量依赖性。我们的结果提供了证据，证明胸腺提取物具有显着的抗氧化，抗凝和抗炎作用，因此证明了这些植物在治疗某些炎症和心血管疾病中的广泛用途。