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Surgical management and prognostic factors of spinal metastatic tumors
Egyptian Journal of Neurosurgery ( IF 0.7 ) Pub Date : 2020-03-23 , DOI: 10.1186/s41984-020-00080-z
Wael A. A. Elmesallamy , Mahmoud M. Taha

This study aims to evaluate different prognostic factors after surgical management of metastatic spinal tumors regarding clinical condition, preoperative investigations, histopathological results, and surgical data. Seventy patients diagnosed as metastatic spinal tumors with neurological deficits and/or unstable spine operated for spinal decompression with or without instrumental fixation according to Spinal Instability Neoplastic Score (SINS) at our institute during the period from May 2014 to October 2018 with follow-up at least 9 months. Lymphoma metastases were the commonest spinal metastases of 23% with significant p value = 0.001, males and ages above 50 years old were significantly affected. High vascularity and bone invasion were significant operative findings. Significant good prognostic factors for both survival and Klekampe score improvement were paretic patients, > 15 preoperative Klekampe score, early surgery, ≤ 3 vertebral affection, extradural tumor location, gross total resection, and metastatic tumors from multiple myeloma, thyroid gland, lymphoma, and prostatic gland. Early surgeries aiming neural decompression and keeping spinal stability according to Spinal Instability Neoplastic Score for patients with spinal metastases are the main hope for better survival and neurological improvement.

中文翻译:

脊柱转移性肿瘤的外科治疗和预后因素

本研究旨在评估转移性脊柱肿瘤手术治疗后有关临床状况,术前检查,组织病理学结果和手术数据的不同预后因素。根据2014年5月至2018年10月在我院进行的脊柱不稳性肿瘤评分(SINS),有70例被诊断为具有神经功能缺损和/或脊柱不稳定的转移性脊柱肿瘤的患者,根据脊柱不稳性肿瘤评分(SINS),在有或无工具固定的情况下进行了脊柱减压术。至少9个月。淋巴瘤转移是最常见的脊柱转移,占23%,p值显着为0.001,男性和50岁以上的年龄明显受到影响。高血管和骨浸润是重要的手术发现。存活率和Klekampe评分改善的重要良好预后因素是:阵发性患者,> 15术前Klekampe评分,早期手术,≤3椎骨病变,硬膜外肿瘤位置,大体总切除以及多发性骨髓瘤,甲状腺,淋巴瘤和前列腺。早期针对脊柱转移瘤患者进行神经减压并根据脊柱不稳定性肿瘤评分保持脊柱稳定性的手术是改善生存和改善神经功能的主要希望。
更新日期:2020-03-23
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