Osteoporosis is a disease of the bones in which the density of the bones decreases. The prevalence of this disease greatly varies in different populations of the world. Numerous studies have been investigated VDR gene polymorphisms as osteoporosis risk in different ethnic groups. In present meta-analysis, the aim is to find out the role of VDR gene polymorphisms (FokI, BsmI, ApaI, and TaqI) in osteoporosis risk. Suitable case-control studies for present meta-analysis were retrieved from four electronic databases. Open Meta-Analyst program was used for statistical analyses. Studies investigated BsmI (65 studies; 6880 cases/8049 controls), ApaI (31 studies; 3763 cases/3934 controls), FokI (18 studies; 1895 cases/1722 controls), and TaqI (26 studies; 2458 cases/2895 controls) polymorphisms that were included in the present meta-analysis. A significant association was found between the dominant model of FokI (ORff + Ffvs.FF = 1.19, 95% CI = 1.04–1.36, p = 0.01, I2 = 39.36%) in the overall analysis and recessive model of the Caucasian population of TaqI polymorphism (ORTT + Ttvs.tt = 1.35, 95% CI = 1.11–1.63, p = 0.002, I2 = 50.07%) with osteoporosis. On the other hand, no such effect is found in any other genetic models and in any other gene polymorphisms of the overall analyses or sub-group analyses. In conclusion, the authors found that the dominant model of FokI in the overall analysis and recessive model of TaqI in the Caucasian population are significantly associated with the development of osteoporosis.

中文翻译：

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维生素 D 受体 (VDR) 基因 FokI、BsmI、ApaI 和 TaqI 多态性与骨质疏松症风险：荟萃分析

骨质疏松症是骨骼密度降低的骨骼疾病。这种疾病的流行在世界不同人群中差异很大。许多研究已经将 VDR 基因多态性作为不同种族的骨质疏松症风险进行了调查。在目前的荟萃分析中，目的是找出 VDR 基因多态性（FokI、BsmI、ApaI 和 TaqI）在骨质疏松症风险中的作用。从四个电子数据库中检索了适合当前荟萃分析的病例对照研究。Open Meta-Analyst 程序用于统计分析。研究调查了 BsmI（65 项研究；6880 例/8049 例对照）、ApaI（31 项研究；3763 例/3934 对照）、FokI（18 项研究；1895 例/1722 对照）和 TaqI（26 项研究；2458 例/2895 对照）本荟萃分析中包括的多态性。在总体分析中发现 FokI 的显性模型 (ORff + Ffvs.FF = 1.19, 95% CI = 1.04–1.36, p = 0.01, I2 = 39.36%) 与 TaqI 高加索人群的隐性模型之间存在显着关联骨质疏松症的多态性（ORTT + Ttvs.tt = 1.35，95% CI = 1.11–1.63，p = 0.002，I2 = 50.07%）。另一方面，在任何其他遗传模型和整体分析或亚组分析的任何其他基因多态性中没有发现这种影响。综上所述，作者发现总体分析中FokI的显性模型和白种人人群中TaqI的隐性模型与骨质疏松症的发展显着相关。36%) 在 TaqI 多态性 (ORTT + Ttvs.tt = 1.35, 95% CI = 1.11–1.63, p = 0.002, I2 = 50.07%) 与骨质疏松症的高加索人群的整体分析和隐性模型中。另一方面，在任何其他遗传模型和整体分析或亚组分析的任何其他基因多态性中没有发现这种影响。综上所述，作者发现总体分析中FokI的显性模型和白种人人群中TaqI的隐性模型与骨质疏松症的发展显着相关。36%) 在 TaqI 多态性 (ORTT + Ttvs.tt = 1.35, 95% CI = 1.11–1.63, p = 0.002, I2 = 50.07%) 与骨质疏松症的高加索人群的整体分析和隐性模型中。另一方面，在任何其他遗传模型和整体分析或亚组分析的任何其他基因多态性中没有发现这种影响。综上所述，作者发现总体分析中FokI的显性模型和白种人人群中TaqI的隐性模型与骨质疏松症的发展显着相关。