Strong evidence supports the involvement of inflammation processes in the development and progression of Parkinson’s disease (PD), where increasingly correlations have been identified between genetic variations in inflammation-related genes and PD. However, data varies between studies. Therefore, we conducted a meta-analysis to clarify associations between inflammation-related gene polymorphisms and PD risk. All studies were identified through online databases. Pooled and stratified groups based on racial descent were assembled to evaluate associations between polymorphisms and PD. The pooled results showed that protective effects for PD were observed for (1) IL-1α -889 C/T in Asian populations (T vs. C, OR = 0.831, P = 0.031; TT + CT vs. CC, OR = 0.827, P = 0.049); (2) IL-6 -176 G/C in Caucasian populations (CC + GC vs. GG, OR = 0.656, P = 0.000; GC vs. GG, OR = 0.673, P = 0.000); (3) IL-8 -251 A/T (T vs. A, OR = 0.812, P = 0.041; TT vs. AT + AA, OR = 0.663, P = 0.012), particularly in Caucasian populations (TT vs. AT + AA, OR = 0.639, P = 0.010); (4) IL-10 -819 T/C (C vs. T, OR = 0.742, P = 0.034); (5) IL-18 -607 C/A (AA + CA vs. CC, OR = 0.597, P = 0.015; CA vs. CC, OR = 0.534, P = 0.005), and (6) CCR2 +190 G/A (AA vs. GA + GG, OR = 0.552, P = 0.018; AA vs. GG; OR = 0.554; 95% CI 0.336–0.914, P = 0.005). An increased risk of PD was associated with IL-10 -1082 G/A in Asian populations (A vs. G, OR = 1.731, P = 0.000; AA + GA vs. GG, OR = 1.910, P = 0.000). No significant associations with PD were observed for polymorphisms in IL-1β -511 C/T, IL-10 -592 C/A, IL-18 -137 G/C, TNFα -863 C/A, TNFα -857 C/T, TNFα -308 G/A, IFNΥ +874 T/A, and MCP1/CCL2 +2518 A/G. We suggest that IL-1α -889, IL-6 -176, IL-8 -251, IL-10 -1082, IL-10 -819, IL-18 -607, and CCR2 +190 polymorphisms may be associated with PD risk; however, further studies must verify these conclusions.

中文翻译：

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与帕金森病相关的炎症相关基因多态性：更新的荟萃分析

强有力的证据支持炎症过程参与帕金森病 (PD) 的发展和进展，其中越来越多的炎症相关基因的遗传变异与 PD 之间的相关性已被确定。然而，研究之间的数据不同。因此，我们进行了一项荟萃分析，以阐明炎症相关基因多态性与 PD 风险之间的关联。所有研究均通过在线数据库确定。汇集了基于种族血统的合并和分层组，以评估多态性和 PD 之间的关联。汇总结果表明，在亚洲人群中观察到 (1) IL-1α -889 C/T 对 PD 的保护作用（T 对 C，OR = 0.831，P = 0.031；TT + CT 对 CC，OR = 0.827 , P = 0.049); (2) 白种人人群中IL-6 -176 G/C（CC+GC vs.GG，OR=0.656，P=0.000；GC 与 GG，OR = 0.673，P = 0.000)；(3) IL-8 -251 A/T（T vs. A, OR = 0.812, P = 0.041; TT vs. AT + AA, OR = 0.663, P = 0.012），特别是在白种人人群中（TT vs. AT + AA，OR = 0.639，P = 0.010)；(4) IL-10 -819 T/C (C vs. T, OR = 0.742, P = 0.034); (5) IL-18 -607 C/A (AA + CA vs. CC, OR = 0.597, P = 0.015; CA vs. CC, OR = 0.534, P = 0.005), (6) CCR2 +190 G/ A（AA 与 GA + GG，OR = 0.552，P = 0.018；AA 与 GG；OR = 0.554；95% CI 0.336–0.914，P = 0.005）。在亚洲人群中，PD 风险增加与 IL-10 -1082 G/A 相关（A 与 G，OR = 1.731，P = 0.000；AA + GA 与 GG，OR = 1.910，P = 0.000）。没有观察到 IL-1β -511 C/T、IL-10 -592 C/A、IL-18 -137 G/C、TNFα -863 C/A、TNFα -857 C/T 的多态性与 PD 的显着关联、TNFα -308 G/A、IFNΥ +874 T/A 和 MCP1/CCL2 +2518 A/G。我们建议 IL-1α -889，IL-6 -176、IL-8 -251、IL-10 -1082、IL-10 -819、IL-18 -607 和 CCR2 +190 多态性可能与 PD 风险相关；然而，进一步的研究必须验证这些结论。