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Hepatoprotective potentials of Acridocarpus orientalis in mice
Clinical Phytoscience Pub Date : 2020-06-04 , DOI: 10.1186/s40816-020-00184-x
Mohamed Lotfy , Rasheed Al-Hammadi , Abdul Rasheed Palakkott , Javed Yasin , Suleiman Al-Hammadi , Taoufik Ksiksi

Overdose of paracetamol affects liver cells leading to cell death. This is done through hepatic necrosis, which is characterized by a rupture of the plasma membrane. A variety of investigations has been conducted using herbal extracts to assess liver toxicity induced by paracetamol. Here we examined herbal plant species, Acridocarpus orientalis (A. orientalis), ethanolic extract to study its potential to protect against hepatotoxicity in mice. Serum alanine transaminase (ALT), aspartate transaminase (AST) and reduced glutathione (GSH) enzymes were estimated for all mice groups. A phytochemical screening was also conducted. Phytochemical screening showed that A. orientalis contains flavonoids, tannins, carbohydrates and phenolics derivatives. A. orientalis pretreatment showed significant reduction of liver marker enzymes ALT and AST in almost all concentrations. Furthermore, serum GSH levels were significantly increased in A. orientalis pretreated mice groups. In addition, a reduction in liver weights in pretreated mice with A. orientalis showed significant weight loss at dose 250 mg/kg BW (P < 0.05). Moreover, the histological liver analysis showed near normal restoration of liver architecture in A. orientalis pretreated mice. pretreatment with A. orientalis protects mice against heplatotoxic adverse effects of paracetamol as indicated by reduction of serum ALT and AST enzymes, with elevation of GSH antioxidant protective enzyme, which may have contributed to the main hepatoprotective action of A. orientalis.

中文翻译:

刺五加对小鼠的保肝潜力

扑热息痛的过量使用会影响肝细胞,导致细胞死亡。这是通过肝坏死来完成的,肝坏死的特征在于质膜的破裂。已经使用草药提取物进行了各种研究,以评估扑热息痛引起的肝毒性。在这里,我们检查了草药植物物种东方侧柏(A. Orientalis),乙醇提取物,以研究其预防小鼠肝毒性的潜力。估计所有小鼠组的血清丙氨酸转氨酶(ALT),天冬氨酸转氨酶(AST)和还原型谷胱甘肽(GSH)酶。还进行了植物化学筛选。植物化学筛选显示东方侧柏含有类黄酮,单宁,碳水化合物和酚类衍生物。一种。Orientalis预处理显示几乎所有浓度的肝脏标志物酶ALT和AST均显着降低。此外,在东方曲霉预处理的小鼠组中,血清GSH水平显着增加。另外,在250 mg / kg BW剂量下,东方曲霉预处理小鼠的肝脏重量减少显示出明显的体重减轻(P <0.05)。此外,肝组织学分析显示,东方侧柏预处理小鼠的肝脏结构几乎恢复正常。东方农杆菌的预处理可保护小鼠免受扑热息痛的肝毒性不良反应,如血清ALT和AST酶的降低以及GSH抗氧化保护酶的升高所表明的那样,这可能有助于东方农杆菌的主要肝保护作用。在东方曲霉预处理的小鼠组中,血清GSH水平显着升高。另外,在250 mg / kg BW剂量下,东方曲霉预处理小鼠的肝脏重量减少显示出明显的体重减轻(P <0.05)。此外,肝组织学分析显示,东方侧柏预处理小鼠的肝脏结构几乎恢复正常。东方A.预处理可以保护小鼠免受扑热息痛的肝毒性不良反应,如血清ALT和AST酶降低,以及GSH抗氧化保护酶的升高,这可能是东方A.的主要肝保护作用。在东方曲霉预处理的小鼠组中,血清GSH水平显着升高。此外,在250 mg / kg BW剂量下,东方曲霉预处理小鼠的肝脏重量减少显示出明显的体重减轻(P <0.05)。此外,肝组织学分析显示,东方侧柏预处理小鼠的肝脏结构几乎恢复正常。东方A.预处理可以保护小鼠免受扑热息痛的肝毒性不良反应,如血清ALT和AST酶降低,以及GSH抗氧化保护酶的升高,这可能是东方A.的主要肝保护作用。肝脏组织学分析显示,东方侧柏预处理小鼠的肝脏结构几乎恢复正常。东方农杆菌的预处理可保护小鼠免受扑热息痛的肝毒性不良反应,如血清ALT和AST酶的降低以及GSH抗氧化保护酶的升高所表明的那样,这可能有助于东方农杆菌的主要肝保护作用。肝脏组织学分析显示,东方侧柏预处理小鼠的肝脏结构几乎恢复正常。东方农杆菌的预处理可保护小鼠免受扑热息痛的肝毒性不良反应,如血清ALT和AST酶的降低以及GSH抗氧化保护酶的升高所表明的那样,这可能有助于东方农杆菌的主要肝保护作用。
更新日期:2020-06-04
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