Various parts i.e., stem bark, leaf, root and flower of Neolamarckia cadamba (Roxb.) Bosser has been extensively used by traditional practitioners to treat all types of diabetes. Our present study investigated the antidiabetic property of the extract from its flower and evaluated its traditional use for diabetes. Phenolic contents were found to be higher in the methanol soluble fraction (MESF) (228.16 ± 0.32 GAE/g of sample) while flavonoids were greater in quantity in the chloroform soluble fraction (CSF) (291 ± 5.99 QE/g of sample). The MESF showed the highest free radical scavenging and α-amylase inhibitory potential with IC50 value of 30.52 ± 2.40 and 6.26 ± 0.82 μg/mL respectively and both the values were promising when compared to the individual standards. Highest reduction of blood glucose level were observed when the N. cadamba flower extract (NCFE) were given (not in combination with metformin) orally for 2 weeks. NMCE at 500 mg/kg resulted 60.2% (p < 0.05) reduction of blood glucose in the diabetic group, comparable with the effect of standard metformin (68.4%). Gain in body weight were also observed in the test groups indicating an overall improvement of health in the diabetic rats. The extract of Neolamarckia cadamba (Roxb.) flower is rich in phenolic and flavonoid compounds attributing to its potent in vitro antioxidant and α-amylase inhibitory potential. Oral administration of NCFE also resulted in a significant (p < 0.05) dose dependent reduction of blood glucose level in diabetic rats, while no synergistic activity was observed when it was given in combination with metformin. These findings imply the possible pharmacological mechanisms behind the antidiabetic property of NCFE could be: inhibition of α-amylase and delaying the absorption of glucose from the intestine, secondly possessing ‘metformin like’ activity such as increasing cellular uptake and glycolysis of glucose, reducing gluconeogenesis in the liver etc. This study also for the first time provides scientific evidence in favor of the traditional use N. cadamba flower against diabetes and demands future study in order to isolate and characterize the bioactive compounds responsible for such bioactivities.

中文翻译：

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的抗糖尿病活性团花（的罗）Bosser花提取物四氧嘧啶诱导的糖尿病大鼠

Neosmarckia cadamba（Roxb。）Bosser的茎，树皮，叶，根和花的各个部分已被传统医生广泛用于治疗所有类型的糖尿病。我们目前的研究调查了其花提取物的抗糖尿病特性，并评估了其在糖尿病中的传统用途。发现甲醇可溶级分（MESF）中的酚类含量较高（228.16±0.32 GAE / g样品），而氯仿可溶级分（CSF）中的类黄酮含量更高（291±5.99 QE / g样品）。MESF表现出最高的自由基清除能力和α-淀粉酶抑制潜能，IC50值分别为30.52±2.40和6.26±0.82μg/ mL，与单独的标准物相比，这两个值都是有希望的。当N.时，血糖水平降低最高。口服（未与二甲双胍合用）卡丹巴花提取物（NCFE）2周。糖尿病组500 mg / kg NMCE可使血糖降低60.2％（p <0.05），与标准二甲双胍的疗效相当（68.4％）。在测试组中还观察到体重增加，表明糖尿病大鼠的健康总体改善。Neolamarckia cadamba（Roxb。）花的提取物富含酚类和黄酮类化合物，这归因于其强大的体外抗氧化剂和α-淀粉酶抑制潜力。口服NCFE还可导致糖尿病大鼠血糖水平显着（p <0.05）剂量依赖性降低，而与二甲双胍联合使用时未观察到协同活性。