Lepidium pinnatifidum is a multipurpose, beneficial plant and known well for its indigenous therapeutic standards. Current study is aimed to investigate antioxidant and anti-inflammatory potency of Lepidium pinnatifidum. L. pinnatifidum dried powder was extracted with crude methanol (LPM) and then fractionated with various solvents to get respective fractions, termed as, n-hexane (LPH), chloroform (LPC), ethyl acetate (LPE), butanol (LPB) and the aqueous fraction (LPA). Fractions were evaluated for total flavonoid and phenolic content. Antioxidant profile was quantified via an array of antioxidant assays. Anti inflammatory activity was evaluated in vitro, and further assessed by in vivo study in Sprague Dawley rat. Total phenolics (TPC) range from 48.15 ± 1.03–241.23 ± 1.07 mg GAE/g while total flavonoids (TFC) quantified were 16.32 ± 1.14–136.32 ± 1.14 mg RE/g. The in vitro antioxidant assays exhibited remarkable radicals scavenging action in different assays. Substantial positive correlation was instituted between TPC, TFC and various antioxidant assays. Inhibition of the heat induced protein denaturation reflected anti inflammatory potency, further supported by in vivo carrageenan induced paw edema. The obtained results lead to suggesting the therapeutic perspective of L. pinnatifidum in oxidative stress and inflammation associated ailments. The bio active ingredients behind its potential protectivity needs to be further confirmed.

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披头草抗氧化和抗炎能力的评估

细叶披头草是一种多用途的有益植物，以其本地治疗标准而闻名。当前的研究旨在研究尖顶披风的抗氧化和抗炎功效。用粗甲醇（LPM）提取品尼特干干燥粉末，然后用各种溶剂进行分馏以获得相应的馏分，分别称为正己烷（LPH），氯仿（LPC），乙酸乙酯（LPE），丁醇（LPB）和水性馏分（LPA）。评价各部分的总类黄酮和酚含量。抗氧化剂谱通过一系列抗氧化剂测定定量。在体外评估抗炎活性，并通过在Sprague Dawley大鼠中的体内研究进一步评估抗炎活性。总酚（TPC）范围为48.15±1.03–241.23±1.07 mg GAE / g，而定量的总黄酮（TFC）为16.32±1.14–136。32±1.14毫克RE / g。体外抗氧化剂测定在不同测定中显示出显着的自由基清除作用。TPC，TFC和各种抗氧化剂测定之间建立了显着的正相关。热诱导的蛋白质变性的抑制反映了抗炎效力，体内角叉菜胶诱导的爪水肿进一步支持了这种作用。所获得的结果提示了Pinnatifidum在氧化应激和炎症相关疾病中的治疗前景。其潜在保护性背后的生物活性成分需要进一步确认。热诱导的蛋白质变性的抑制反映了抗炎效力，体内角叉菜胶诱导的爪水肿进一步支持了这种作用。所获得的结果提示了Pinnatifidum在氧化应激和炎症相关疾病中的治疗前景。其潜在保护性背后的生物活性成分需要进一步确认。热诱导的蛋白质变性的抑制反映了抗炎效力，体内角叉菜胶诱导的爪水肿进一步支持了这种作用。所获得的结果提示了Pinnatifidum在氧化应激和炎症相关疾病中的治疗前景。其潜在保护性背后的生物活性成分需要进一步确认。