Flaxseed has emerged as a potential source of bioactive components that can be utilized in routine diet to address lifestyle disorders. In this context, three studies were carried out on the basis of induction therapies i.e. Study I (Normal diet), Study II (Hyperglycemic diet; 40% sucrose) and Study III (Hypercholesterolemic diet; 1.5% cholesterol) using Sprague Dawley rats. Each study was further split into three groups based on diets; Control (free from flaxseed powder or extract), Functional diet (incorporation of flaxseed powder; 10%) and Nutraceutical diet (inclusion of ethanolic extract of flaxseed; 5%). During experimental period, hyperglycemic and hyperlipidemic parameters were evaluated alongside, alterations in hematological aspects were also assessed. Feed intake and body weight demonstrated significant response (p < 0.05) of diets and study intervals however, water intake was substantially influenced by study intervals. In study II (hyperglycemic rats), maximum decline in glucose level was recorded (9.02%) in rats administered with extract based diet. In the same group, maximum increase in insulin (5.90%) was noted. Regarding lipid profile, the bioevaluation trials revealed maximum reduction in serum cholesterol (13.10%) in study III (hypercholesterolemic rats) on the provision of flaxseed extract (nutraceutical diet) followed by flaxseed powder (functional diet) i.e. 7.85%. Further, maximum decrease in low density lipoprotein-cholesterol (LDL-c) was reported i.e. 14.28% on supplementation of flaxseed extract to hypercholesterolemic rats. Thus, flaxseed extract based intervention has shown higher bioefficacy to address hyperglycemia and hypercholesterolemia in comparison to flaxseed powder.

中文翻译：

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Sprague Dawley大鼠对亚麻籽粉和提取物针对高血糖和高胆固醇血症的生物评估

亚麻籽已成为生物活性成分的潜在来源，可用于日常饮食中以解决生活方式障碍。在此背景下，使用Sprague Dawley大鼠在诱导疗法的基础上进行了三项研究，即研究I（正常饮食），研究II（高血糖饮食； 40％蔗糖）和研究III（高胆固醇饮食； 1.5％胆固醇）。根据饮食，将每项研究进一步分为三组。对照（不含亚麻籽粉或提取物），功能饮食（掺入亚麻籽粉； 10％）和营养食品（包含亚麻籽的乙醇提取物； 5％）。在实验期间，同时评估了高血糖和高血脂参数，还评估了血液学方面的变化。采食量和体重表现出显着的反应（p <0。05）饮食和研究间隔，但是饮水量受研究间隔的影响很大。在研究II（高血糖大鼠）中，记录了以提取物为基础饮食的大鼠的葡萄糖水平最大下降（9.02％）。在同一组中，发现胰岛素的最大增加量（5.90％）。关于脂质分布，生物评估试验显示，在研究III（高胆固醇血症的大鼠）中，先提供亚麻籽提取物（营养饮食），再添加亚麻籽粉（功能饮食），血清胆固醇降低最多（13.10％），即7.85％。此外，据报导，在高胆固醇血症大鼠中补充亚麻籽提取物后，低密度脂蛋白胆固醇（LDL-c）最大降低，即14.28％。从而，