Glaucoma is a complex multivariate disorder characterized by retinal ganglion cell (RGC) loss and optic nerve degeneration. Evidence suggests the role of estradiol (E2) and the etiology of glaucoma. Therefore, this present study evaluates the association between estrogen-signaling pathways and the risk of open-angle glaucoma (OAG). Meta-analysis was performed from available studies that investigated intraocular pressure (IOP) in patients treated with or without hormone replacement therapy (HRT) and studies that evaluated the associations between estrogen receptor (ER) polymorphisms and the risk of OAG. The pooled result showed that HRT had a positive effect in lowering IOP. Moreover, ERβ polymorphisms showed a significant association with the risk of OAG. This report supports the notion that estrogen-signaling pathways play a pivotal role in the development of OAG.

中文翻译：

---

雌激素信号通路与开角型青光眼易感性的关联

青光眼是一种复杂的多变量疾病，其特征在于视网膜神经节细胞 (RGC) 损失和视神经变性。有证据表明雌二醇 (E2) 的作用和青光眼的病因。因此，本研究评估了雌激素信号通路与开角型青光眼 (OAG) 风险之间的关联。荟萃分析是从现有研究中进行的，这些研究调查了接受或不接受激素替代疗法 (HRT) 治疗的患者的眼内压 (IOP)，以及评估雌激素受体 (ER) 多态性与 OAG 风险之间关联的研究。汇总结果表明，HRT 在降低眼压方面具有积极作用。此外，ERβ 多态性显示出与 OAG 风险显着相关。