To evaluate the clinical efficacy of concentrated growth factors (CGFs) combined with mineralized collagen (MC) in guided bone regeneration (GBR). A retrospective study involving 29 patients treated with GBR technique, which was performed either CGF and MC complexes or MC alone. Implants were inserted simultaneously and cone-beam computed tomography was taken immediately, at 3 and 6 months postoperation. Questionnaires were completed by all patients so as to evaluate the main symptoms and daily activities during the first week after surgery. The outcomes of the two groups were statistically compared. All implants healed uneventfully. Patients in both groups suffered from different levels of discomfort for the reason of swelling, pain and chewing impairment on 1–2 days. Meanwhile, swelling of the Trial group was weaker than the Control group. When compared with the Control group, pain levels in Trial group were more rapidly reduced and patients took fewer analgesics from Day 3. Furthermore, the reconstitution mean value of the graft was thicker at 3 and 6 months in Trial group. CGFs complex with MC were beneficial to relieve the clinical symptoms, promote the peri-implant bone regeneration and shorten the healing time.

中文翻译：

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浓缩生长因子结合矿化胶原蛋白对生活质量和引导性骨再生的骨重建的功效。

为了评估浓缩生长因子（CGF）结合矿化胶原蛋白（MC）在引导性骨再生（GBR）中的临床疗效。一项回顾性研究涉及29名接受GBR技术治疗的患者，该研究既进行了CGF和MC复合物，也进行了单独的MC。同时植入植入物，并在术后3个月和6个月立即进行锥形束计算机断层扫描。所有患者均完成问卷调查，以评估术后第一周的主要症状和日常活动。对两组的结果进行统计学比较。所有植入物均愈合良好。两组患者在1-2天因肿胀，疼痛和咀嚼障碍而遭受不同程度的不适。同时，试验组的肿胀弱于对照组。与对照组相比，从第3天开始，试验组的疼痛程度更加迅速地减轻，患者使用的止痛药减少了。此外，试验组在3个月和6个月时，移植物的重建平均值更高。CGF与MC的复合物有助于缓解临床症状，促进植入物周围骨的再生并缩短愈合时间。