Dental caries is one of the most common oral diseases in the world. This study was tantamount to investigate the combinatory effects of an amelogenin-derived peptide (called QP5) and fluoride on the remineralization of artificial enamel caries. The peptide QP5 was synthesized and characterized, and the binding capability of the peptide on hydroxyapatite (HA) and demineralized tooth enamel surface was analysed. Then, the mineralization function of the peptide and fluoride was studied through the spontaneous mineralization testing and remineralization on enamel caries in vitro. First, the novel peptide QP5 could bind on the hydroxyapatite and demineralized tooth enamel surfaces. Second, QP5 can transitorily stabilize the formation of amorphous calcium phosphate and direct the transformation into hydroxyapatite crystals alone and in combination with fluoride. In addition, compared to blocks treated by peptide QP5 alone or fluoride, the sample blocks showed significantly higher surface microhardness, lower mineral loss and shallower lesion depth after treatment with a combination of QP5 and fluoride at high or low concentrations. The peptide QP5 could control the crystallization of hydroxyapatite, and combinatory application of peptide QP5 and fluoride had a potential synergistic effect on the remineralization of enamel caries.

中文翻译：

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牙釉质衍生肽和氟化物在体外对牙釉质龋齿进行再矿化。


龋齿是世界上最常见的口腔疾病之一。这项研究相当于研究牙釉蛋白衍生肽（称为 QP5）和氟化物对人工牙釉质龋齿再矿化的联合作用。合成并表征了肽QP5，并分析了肽对羟基磷灰石（HA）和脱矿牙釉质表面的结合能力。然后通过体外牙釉质龋齿的自发矿化试验和再矿化研究肽和氟化物的矿化功能。首先，新型肽 QP5 可以结合在羟基磷灰石和脱矿牙釉质表面。其次，QP5可以暂时稳定无定形磷酸钙的形成，并直接转化为单独的羟基磷灰石晶体以及与氟化物结合的羟基磷灰石晶体。此外，与单独使用肽QP5或氟化物处理的块相比，在高或低浓度的QP5和氟化物组合处理后，样品块表现出显着更高的表面显微硬度、更低的矿物质损失和更浅的病变深度。肽QP5可以控制羟基磷灰石的结晶，肽QP5与氟化物的联合应用对牙釉质龋齿的再矿化具有潜在的协同作用。