Keratinocytes produce cytokines and participate in immune responses and skin healing. Poly(I:C) is a ligand for TLR3 that induces the production of IL-8 in skin and promotes wound repair. Bee venom (BV) has many effects on skin, and Nakashima et al. show that BV synergizes with various TLR ligands to enhance the IL-8 production in HaCaT cells (a human keratinocyte cell line). This is especially marked for high-molecular-weight poly(I:C), with responses to TLR1/TLR2 and TLR2/TLR6 ligands also enhanced. BV-sPLA2 is the active component for this synergy not only in HaCaT cells but also in primary human epidermal keratinocytes and the enzyme activity is required. Hydrolysis of keratinocyte membrane phospholipids is also increased. BV-sPLA2 increases...

中文翻译：

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在这个问题上

角质形成细胞产生细胞因子并参与免疫反应和皮肤愈合。聚（I：C）是TLR3的配体，可诱导皮肤中IL-8的产生并促进伤口修复。蜂毒（BV）对皮肤有许多作用，中岛等人也是如此。证明BV与各种TLR配体协同作用以增强HaCaT细胞（人角质形成细胞系）中IL-8的产生。对于高分子量聚（I：C）尤其如此，对TLR1 / TLR2和TLR2 / TLR6配体的反应也得到增强。BV-sPLA2不仅在HaCaT细胞中而且在原代人表皮角质形成细胞中都是这种协同作用的活性成分，因此需要酶活性。角质形成细胞膜磷脂的水解也增加。BV-sPLA2增加...