Inflammation is facilitated largely by macrophages and other white blood cells, which recognize and respond to evolutionarily conserved damage-associated molecular patterns that are released upon tissue injury and cell stress. Damage-associated molecular patterns are known to bind Toll-like receptors (TLRs) and initiate inflammatory responses through MyD88-dependent NF-KB signaling. Biomaterial implantation activates the innate immune system, resulting in a chronic inflammatory response known as a foreign body reaction (FBR). In this review, the authors discuss the current understanding of damage-initiated TLR signaling in the FBR and the significance of this response in the success of implanted devices.

中文翻译：

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Toll 样受体信号在巨噬细胞对植入材料的反应中的作用

炎症主要由巨噬细胞和其他白细胞促进，它们识别并响应进化上保守的损伤相关分子模式，这些分子模式在组织损伤和细胞应激时释放。已知损伤相关分子模式结合 Toll 样受体 (TLR) 并通过 MyD88 依赖性 NF-KB 信号传导启动炎症反应。生物材料植入激活先天免疫系统，导致称为异物反应 (FBR) 的慢性炎症反应。在这篇综述中，作者讨论了目前对 FBR 中损伤引发的 TLR 信号的理解以及这种反应对植入装置成功的重要性。