This work focuses on the functionalization of agave xylan-type hemicellulose functionalized with trimethoxysilylpropylmethacrylate and crosslinked with N -vinylcaprolactam to obtain a thermoresponsive material for potential applications in drug delivery. The hydrogels showed an interconnected and porous architecture with a lower critical solution temperature (LCST) close to poly( N -vinylcaprolactam)’s (PNVCL) LCST. These materials showed a good capacity to load ciprofloxacin (in the range 9.5 × 10 −3 –8.4 × 10 −3 mg/mL), above the minimum inhibitory concentration (MIC ≤ 0.004 × 10 −3 –0.5 × 10 −3 mg/mL) for gram-positive and gram-negative bacteria. The hybrid hydrogel inhibited the growth of Escherichia coli , Staphylococcus aureus, and Pseudomonas aeruginosa .

中文翻译：

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基于龙舌兰甘蔗渣木聚糖型半纤维素的热敏混合水凝胶的开发：表征和抗菌活性

这项工作的重点是用甲基丙烯酸三甲氧基甲硅烷基丙酯官能化并与 N-乙烯基己内酰胺交联的龙舌兰木聚糖型半纤维素的官能化，以获得用于药物递送的潜在应用的热响应材料。水凝胶显示出相互连接的多孔结构，其临界溶解温度 (LCST) 接近于聚 (N-乙烯基己内酰胺) (PNVCL) LCST。这些材料显示出良好的环丙沙星负载能力（范围为 9.5 × 10 -3 –8.4 × 10 -3 mg/mL），高于最低抑菌浓度（MIC ≤ 0.004 × 10 -3 –0.5 × 10 -3 mg/mL） mL) 用于革兰氏阳性菌和革兰氏阴性菌。混合水凝胶抑制大肠杆菌、金黄色葡萄球菌和铜绿假单胞菌的生长。