MRS Communications ( IF 1.9 ) Pub Date : 2020-04-30 , DOI: 10.1557/mrc.2020.32 Ricardo Ángel Gutiérrez-Bernal , Daniel Chávez , Gerardo Aguirre-Hernández , Manuel Alatorre-Meda , Amelia Olivas-Sarabia , Domingo Madrigal-Peralta
β-Alanine and its derivatives are important starting materials for the preparation of peptides or compounds with biological activity. In this work, the authors are presenting a new approach for the synthesis of N-alkyl-β-amino acids and N-alkyl-β-amino esters using dendrimeric intermediates in a one-pot reaction, with friendly reaction conditions. Dendrimeric compounds, with a pentaerythritol core, were easy prepared and used to obtain the β-amino acid derivatives and β-amino esters with good yields. This paper presents the first reaction where dendrimers are used for synthesizing organic compounds. Spectroscopic characterization by 1H- and 13C-NMR of dendrimers and final products is also presented.
中文翻译:
由树枝状分子新合成N-烷基-β-氨基酸及其甲酯
β-丙氨酸及其衍生物是制备具有生物活性的肽或化合物的重要起始原料。在这项工作中,作者们提出了一种通过树状中间体在友好反应条件下通过一锅反应合成N-烷基-β-氨基酸和N-烷基-β-氨基酯的新方法。具有季戊四醇核心的树枝状化合物易于制备,并用于以良好的产率获得β-氨基酸衍生物和β-氨基酯。本文介绍了第一个反应,其中使用树枝状大分子合成有机化合物。还介绍了通过1 H-和13 C-NMR对树枝状聚合物和最终产物进行的光谱表征。