Hybrid GMP-polyamine hydrogels as new biocompatible materials for drug encapsulation.,Soft Matter

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Hybrid GMP-polyamine hydrogels as new biocompatible materials for drug encapsulation.
Soft Matter ( IF 2.9 ) Pub Date : 2020-06-10 , DOI: 10.1039/d0sm00704h
Alberto Lopera ₁ , Juan A Aguilar ₂ , Raquel Belda ₂ , Begoña Verdejo ₁ , Jonathan W Steed ₂ , Enrique García-España ₁

Affiliation

Here we present the preparation and characterization of new biocompatible materials for drug encapsulation. These new gels are based on positively charged [1+1] 1H-pyrazole-based azamacrocycles which minimise the electrostatic repulsions between the negatively charged GMP molecules. Rheological measurements confirm the electroneutral hydrogel structure as the most stable for all the GMP–polyamine systems. Nuclear magnetic resonance (NMR) was employed to investigate the kinetics of the hydrogel formation and cryo-scanning electron microscopy (cryo-SEM) was used to obtain information about the hydrogel morphology, which exhibited a non-homogeneous structure with a high degree of cross-linking. It is possible to introduce isoniazid, which is the most employed antibiotic for tuberculosis treatment, into the hydrogels without disrupting the hydrogel structure at appropriate concentrations for oral administration.

中文翻译：

混合GMP-多胺水凝胶作为药物封装的新型生物相容性材料。

在这里，我们介绍用于药物封装的新型生物相容性材料的制备和表征。这些新凝胶基于带正电的[1 + 1] 1 H-吡唑基的氮杂大环化合物，使带负电荷的GMP分子之间的静电排斥最小。流变学测量证实，对于所有GMP-多胺系统，电中性水凝胶结构是最稳定的。使用核磁共振（NMR）研究水凝胶形成的动力学，并使用低温扫描电子显微镜（cryo-SEM）获得有关水凝胶形态的信息，该信息表现出具有高交叉度的非均质结构-链接。可以在水凝胶中引入异烟肼，这是治疗结核病最常用的抗生素，而不会以口服的适当浓度破坏水凝胶的结构。

更新日期：2020-07-22

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