Androgen deprivation therapy (ADT) is widely used in the treatment of testosterone-dependent prostate carcinomas. ADT often increases plasma LDL and HDL cholesterol and triglycerides. The aim was to test whether ADT changes the transfer of lipids to HDL, an important aspect of this metabolism and HDL protective functions, and related parameters. Sixteen volunteers with advanced prostate carcinoma submitted to pharmacological ADT or orchiectomy had plasma collected shortly before and after 6 months of ADT. In vitro transfer of lipids to HDL was performed by incubating plasma with donor emulsion containing radioactive lipids by 1 h at 37 °C. After chemical precipitation of apolipoprotein B-containing lipoprotein, the radioactivity of HDL fraction was counted. ADT reduced testosterone to nearly undetectable levels and markedly diminished PSA. ADT increased the body weight but glycemia, triglycerides, LDL and HDL cholesterol, HDL lipid composition and CETP concentration were unchanged. However, ADT increased the plasma unesterified cholesterol concentration (48 ± 12 vs 56 ± 12 mg/dL, p = 0.019) and LCAT concentration (7.15 ± 1.81 vs 8.01 ± 1.55μg/mL, p = 0.020). Transfer of unesterified (7.32 ± 1.09 vs 8.18 ± 1.52%, p < 0.05) and esterified cholesterol (6.15 ± 0.69 vs 6.94 ± 1.29%, p < 0.01) and of triglycerides (6.37 ± 0.43 vs 7.18 ± 0.91%, p < 0.001) to HDL were increased after ADT. Phospholipid transfer was unchanged. Increase in transfer of unesterified and esterified cholesterol protects against cardiovascular disease, as shown previously, and increased LCAT favors cholesterol esterification and facilitates the reverse cholesterol transport. Thus, our results suggest that ADT may offer anti-atherosclerosis protection by improving HDL functional properties. This could counteract, at least partially, the eventual worse effects on plasma lipids.

中文翻译：

---

雄激素剥夺疗法提高了高密度脂蛋白 (HDL) 在前列腺癌患者中接受胆固醇和其他脂质的体外能力。

雄激素剥夺疗法（ADT）广泛用于治疗睾酮依赖性前列腺癌。ADT 通常会增加血浆 LDL 和 HDL 胆固醇和甘油三酯。目的是测试 ADT 是否会改变脂质向 HDL 的转移，这是这种代谢和 HDL 保护功能的一个重要方面，以及相关参数。接受药物 ADT 或睾丸切除术的 16 名晚期前列腺癌志愿者在 ADT 6 个月之前和之后不久收集了血浆。通过将血浆与含有放射性脂质的供体乳液在 37°C 下孵育 1 小时，进行脂质到 HDL 的体外转移。含载脂蛋白B的脂蛋白化学沉淀后，计算HDL级分的放射性。ADT 将睾酮降低到几乎检测不到的水平，并显着降低了 PSA。ADT 增加了体重，但血糖、甘油三酯、低密度脂蛋白和高密度脂蛋白胆固醇、高密度脂蛋白脂质成分和 CETP 浓度没有变化。然而，ADT 增加了血浆未酯化胆固醇浓度（48 ± 12 对 56 ± 12 mg/dL，p = 0.019）和 LCAT 浓度（7.15 ± 1.81 对 8.01 ± 1.55μg/mL，p = 0.020）。未酯化胆固醇（7.32 ± 1.09 对 8.18 ± 1.52%，p < 0.05）和酯化胆固醇（6.15 ± 0.69 对 6.94 ± 1.29%，p < 0.01）和甘油三酯（6.37 ± 0.483 对 0.19%，p < 0.01）的转移) 到 HDL 在 ADT 后增加。磷脂转移没有变化。如前所述，增加未酯化和酯化胆固醇的转移可以预防心血管疾病，而增加的 LCAT 有利于胆固醇酯化并促进反向胆固醇转运。因此，我们的结果表明 ADT 可能通过改善 HDL 功能特性提供抗动脉粥样硬化保护。这至少可以部分抵消对血脂的最终恶化影响。