当前位置：
X-MOL 学术
›
J. Mater. Chem. B
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
A phosphorylcholine-based zwitterionic copolymer coated ZIF-8 nanodrug with a long circulation time and charged conversion for enhanced chemotherapy.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-06-10 , DOI: 10.1039/d0tb00193g Ruihong Xie 1 , Peng Yang , Shaojun Peng , Yongbin Cao , Xianxian Yao , Shengdi Guo , Wuli Yang
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-06-10 , DOI: 10.1039/d0tb00193g Ruihong Xie 1 , Peng Yang , Shaojun Peng , Yongbin Cao , Xianxian Yao , Shengdi Guo , Wuli Yang
Affiliation
|
In recent years, zeolitic imidazolate framework-8 (ZIF-8) has become an attractive metal organic framework (MOF) material in drug delivery for cancer chemotherapy. However, as a drug delivery system, ZIF-8 still shows some disadvantages, such as short blood circulation time and poor tumor targeting, leading to reduced drug delivery efficiency and unsatisfactory treatment. Herein, we developed a phosphorylcholine-based zwitterionic copolymer coated ZIF-8 nanodrug (DOX@ZIF-8@P(MPC-co-C7A)), and the obtained nanodrug was prepared via a charge-conversional zwitterionic copolymer coating on DOX@ZIF-8 composites. In this system, DOX was encapsulated in the framework of ZIF-8, which could reduce the drug leakage in the bloodstream. The phosphorylcholine-based zwitterionic copolymer effectively extended the blood circulation time, resulting in enhanced tumor accumulation of the nanodrug. Once the nanodrug reached the tumor site, the surface charge of the system could rapidly convert to positive, resulting in an enhanced tumor cellular uptake. Finally, in the acidic environment inside intracellular organelles, DOX will be released rapidly for chemotherapy owing to the fast disintegration of ZIF-8 frameworks. Therefore, the obtained nanodrug could effectively inhibit the growth of A549-bearing tumors (93.2% tumor inhibition rate) with negligible side effects. Overall, this work significantly improved the drug delivery efficiency of ZIF-8, which may pave the way for the biomedical applications of ZIF-8 crystals in anti-tumor drug delivery.
中文翻译：
磷酸胆碱基两性离子共聚物包覆的ZIF-8纳米药物具有较长的循环时间和带电荷的转化作用，可增强化学疗法。
近年来，沸石咪唑酯骨架8（ZIF-8）已成为癌症化疗药物输送中一种有吸引力的金属有机骨架（MOF）材料。然而，作为药物递送系统，ZIF-8仍然显示出一些缺点，例如血液循环时间短和肿瘤靶向性差，导致药物递送效率降低和治疗效果不理想。在这里，我们开发了一种基于磷酸胆碱的两性离子共聚物包被的ZIF-8纳米药物（DOX @ ZIF-8 @ P（MPC - co -C7A）），并通过在DOX @ ZIF-8复合材料上的电荷转换两性离子共聚物涂层。在该系统中，将DOX封装在ZIF-8框架内，这可以减少血液中的药物泄漏。基于磷酰胆碱的两性离子共聚物有效地延长了血液循环时间，从而导致纳米药物的肿瘤积累增强。一旦纳米药物到达肿瘤部位，系统的表面电荷就可以迅速转变为阳性，从而导致肿瘤细胞摄取增加。最后，由于ZIF-8框架的快速分解，在细胞内细胞器内部的酸性环境中，DOX将迅速释放用于化学疗法。因此，所获得的纳米药物可以有效地抑制带有A549的肿瘤的生长（93.2％的肿瘤抑制率），且副作用可忽略不计。总体，
更新日期：2020-07-22
中文翻译：
磷酸胆碱基两性离子共聚物包覆的ZIF-8纳米药物具有较长的循环时间和带电荷的转化作用，可增强化学疗法。
近年来，沸石咪唑酯骨架8（ZIF-8）已成为癌症化疗药物输送中一种有吸引力的金属有机骨架（MOF）材料。然而，作为药物递送系统，ZIF-8仍然显示出一些缺点，例如血液循环时间短和肿瘤靶向性差，导致药物递送效率降低和治疗效果不理想。在这里，我们开发了一种基于磷酸胆碱的两性离子共聚物包被的ZIF-8纳米药物（DOX @ ZIF-8 @ P（MPC - co -C7A）），并通过在DOX @ ZIF-8复合材料上的电荷转换两性离子共聚物涂层。在该系统中，将DOX封装在ZIF-8框架内，这可以减少血液中的药物泄漏。基于磷酰胆碱的两性离子共聚物有效地延长了血液循环时间，从而导致纳米药物的肿瘤积累增强。一旦纳米药物到达肿瘤部位，系统的表面电荷就可以迅速转变为阳性，从而导致肿瘤细胞摄取增加。最后，由于ZIF-8框架的快速分解，在细胞内细胞器内部的酸性环境中，DOX将迅速释放用于化学疗法。因此，所获得的纳米药物可以有效地抑制带有A549的肿瘤的生长（93.2％的肿瘤抑制率），且副作用可忽略不计。总体，
京公网安备 11010802027423号