Mechanism of action of the curcumin cis-diammineplatinum(II) complex as a photocytotoxic agent,Inorganic Chemistry Frontiers

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Mechanism of action of the curcumin cis-diammineplatinum(II) complex as a photocytotoxic agent
Inorganic Chemistry Frontiers ( IF 6.1 ) Pub Date : 2020-06-10 , DOI: 10.1039/d0qi00503g
Eslam Dabbish _{1,

2,

3,

4} , Gloria Mazzone _{1,

2,

3,

4} , Nino Russo _{1,

2,

3,

4} , Emilia Sicilia _{1,

2,

3,

4}

Affiliation

In the search for new and more active anticancer drugs, light-activated compounds are emerging as effective drugs to be used in photodynamic therapy (PDT) and photoactivated chemotherapy (PACT). These clinical treatments are able to overcome severe side effects caused by the conventional Pt(II) complexes in chemotherapy, since the cytotoxic species are released directly into the target regions, reducing toxicity in healthy tissues. The curcumin cis-diammineplatinum(II) complex has been proposed for PACT as it allows the controlled release of aquated diammine–platinum(II) species as a DNA cross-linking agent and curcumin as a potential photosensitizer, thus working as a dual action anticancer agent. The curcumin ligand dissociation upon irradiation with visible light was examined by means of DFT and TD-DFT calculations. The outcomes clearly unraveled the metal-centered triplet states ³MC as active species involved in the photocleavage of curcumin that lead to the formation of aquated platinum species and ruled out the potential activity of such a complex in the dark.

中文翻译：

姜黄素顺二氨铂（II）复合物作为光细胞毒性剂的作用机理

在寻找新的和更具活性的抗癌药物中，光活化化合物正在作为有效的药物出现，可用于光动力疗法（PDT）和光活化化学疗法（PACT）。这些细胞疗法能够克服化学疗法中常规Pt（II）配合物引起的严重副作用，因为细胞毒性物质直接释放到目标区域，从而降低了健康组织的毒性。姜黄素的顺式-diammineplatinum（II）复合物已被建议用于PACT，因为它允许aquated二氨铂的受控释放（II）作为一种DNA交联剂和姜黄素作为一种潜在的光敏剂，因此起着双重作用的抗癌作用。通过DFT和TD-DFT计算来检查在可见光照射下姜黄素配体的解离。结果清楚地阐明了以金属为中心的三重态³ MC作为活性成分参与姜黄素的光裂解，从而导致了水合铂物种的形成，并排除了这种复合物在黑暗中的潜在活性。

更新日期：2020-07-28

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