Palladium-catalyzed dearomative 1,4-difunctionalization of naphthalenes,Chemical Science

当前位置： X-MOL 学术 › Chem. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Palladium-catalyzed dearomative 1,4-difunctionalization of naphthalenes
Chemical Science ( IF 7.6 ) Pub Date : 2020-06-10 , DOI: 10.1039/d0sc02816a
Ping Yang ₁ , Chao Zheng ₁ , Yu-Han Nie ₁ , Shu-Li You ₁

Affiliation

A highly diastereoselective dearomatization of naphthalenes via a Pd-catalyzed 1,4-difunctionalization reaction is described. In the presence of a commercially available palladium precursor and ligand, intramolecular dearomative Heck-type insertion provides π-allylpalladium intermediates which are readily captured by a series of nucleophiles in excellent yields (up to 99%). This reaction features mild conditions, broad substrate scope, and useful transformations of the products.

中文翻译：

钯催化萘的1,4-二官能化脱芳香

描述了通过Pd 催化的 1,4-双官能化反应对萘进行高度非对映选择性脱芳构化。在市售钯前体和配体存在下，分子内脱芳香 Heck 型插入提供了 π-烯丙基钯中间体，该中间体很容易被一系列亲核试剂捕获，产率极好（高达 99%）。该反应条件温和，底物范围广，产物转化效果好。

更新日期：2020-07-08

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11