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Sural Radial Amplitude Ratio: A Study in Healthy Indian Subjects.
Annals of Indian Academy of Neurology ( IF 1.9 ) Pub Date : 2020-05-01 , DOI: 10.4103/aian.aian_321_20 Khushnuma Mansukhani 1 , Mayura Dhonde 2 , Aarthika Sreenivasan 3 , Alika Sharma 4 , Lajita Balakrishnan 5 , Priyanka Chavan 6
Context: The amplitude ratio of sural radial sensory nerve action potential is used as a sensitive measure for the diagnosis of an early distal axonal peripheral neuropathy. There is no age-stratified reference data available. Aim: To establish age-stratified sural radial amplitude ratio (SRAR) reference data in healthy Indian subjects. Study Setting and Design: The study was conducted in the electrodiagnostic laboratory of a tertiary city hospital and is an analytical, prospective, and field trial study. Materials and Methods: A prospective study was conducted on 146 healthy volunteers between 18 and 86 years, stratified into 6 groups, a = 18–30 years, b = 31–40 years, c = 41–50 years, d = 51–60 years, e = 61–70 years, and f = >70 years. Sural: Radial amplitude ratio was calculated. Statistical Methods: Stata 12.1 statistical program was used. Lower limit of SRAR was obtained (mean-2SD of transformed data). ANOVA defined the intergroup variability, and linear regression and Pearson's correlation assessed the statistical significance. Results: The lower limit of normal SRAR, for each age group is as follows: a: 0.30, b: 0.23, c: 0.20, d: 0.17, e: 0.17, and f: 0.08. SRAR of groups a, b, c was significantly different from groups e and f. Similarly, SRAR was significantly different between groups d and f but not between groups d and e or a, b, c, d. Conclusion: This study provides age-stratified reference data for SRAR. There is evidence to suggest that SRAR varies with age; hence, a single value of SRAR should not be used when diagnosing a peripheral neuropathy based on this criterion.
中文翻译：
腓肠径向振幅比：对健康印度受试者的研究。
背景：腓肠桡侧感觉神经动作电位的振幅比被用作诊断早期远端轴突周围神经病的敏感指标。没有可用的年龄分层参考数据。目的：建立健康印度受试者的年龄分层腓肠径向振幅比 (SRAR) 参考数据。研究背景和设计：该研究在某三级城市医院的电诊断实验室进行，是一项分析性、前瞻性和现场试验研究。材料和方法：对 146 名 18 至 86 岁健康志愿者进行了一项前瞻性研究，分为 6 组，a = 18-30 岁，b = 31-40 岁，c = 41-50 岁，d = 51-60 岁年，e = 61–70 年，f = >70 年。 Sural：计算径向振幅比。统计方法：采用Stata 12.1统计程序。获得 SRAR 的下限（转换数据的平均值 - 2SD）。方差分析定义了组间变异性，线性回归和皮尔逊相关性评估了统计显着性。结果：各年龄组的正常SRAR下限如下：a：0.30，b：0.23，c：0.20，d：0.17，e：0.17，f：0.08。 a、b、c组的SRAR与e、f组有显着差异。同样，SRAR 在 d 组和 f 组之间显着不同，但在 d 组和 e 组或 a、b、c、d 组之间没有显着差异。结论：本研究为SRAR提供了年龄分层的参考数据。有证据表明 SRAR 随年龄而变化；因此，根据此标准诊断周围神经病时不应使用 SRAR 的单一值。
更新日期：2020-05-01
Annals of Indian Academy of Neurology ( IF 1.9 ) Pub Date : 2020-05-01 , DOI: 10.4103/aian.aian_321_20 Khushnuma Mansukhani 1 , Mayura Dhonde 2 , Aarthika Sreenivasan 3 , Alika Sharma 4 , Lajita Balakrishnan 5 , Priyanka Chavan 6
Affiliation
Context: The amplitude ratio of sural radial sensory nerve action potential is used as a sensitive measure for the diagnosis of an early distal axonal peripheral neuropathy. There is no age-stratified reference data available. Aim: To establish age-stratified sural radial amplitude ratio (SRAR) reference data in healthy Indian subjects. Study Setting and Design: The study was conducted in the electrodiagnostic laboratory of a tertiary city hospital and is an analytical, prospective, and field trial study. Materials and Methods: A prospective study was conducted on 146 healthy volunteers between 18 and 86 years, stratified into 6 groups, a = 18–30 years, b = 31–40 years, c = 41–50 years, d = 51–60 years, e = 61–70 years, and f = >70 years. Sural: Radial amplitude ratio was calculated. Statistical Methods: Stata 12.1 statistical program was used. Lower limit of SRAR was obtained (mean-2SD of transformed data). ANOVA defined the intergroup variability, and linear regression and Pearson's correlation assessed the statistical significance. Results: The lower limit of normal SRAR, for each age group is as follows: a: 0.30, b: 0.23, c: 0.20, d: 0.17, e: 0.17, and f: 0.08. SRAR of groups a, b, c was significantly different from groups e and f. Similarly, SRAR was significantly different between groups d and f but not between groups d and e or a, b, c, d. Conclusion: This study provides age-stratified reference data for SRAR. There is evidence to suggest that SRAR varies with age; hence, a single value of SRAR should not be used when diagnosing a peripheral neuropathy based on this criterion.
中文翻译：
腓肠径向振幅比：对健康印度受试者的研究。
背景：腓肠桡侧感觉神经动作电位的振幅比被用作诊断早期远端轴突周围神经病的敏感指标。没有可用的年龄分层参考数据。目的：建立健康印度受试者的年龄分层腓肠径向振幅比 (SRAR) 参考数据。研究背景和设计：该研究在某三级城市医院的电诊断实验室进行，是一项分析性、前瞻性和现场试验研究。材料和方法：对 146 名 18 至 86 岁健康志愿者进行了一项前瞻性研究，分为 6 组，a = 18-30 岁，b = 31-40 岁，c = 41-50 岁，d = 51-60 岁年，e = 61–70 年，f = >70 年。 Sural：计算径向振幅比。统计方法：采用Stata 12.1统计程序。获得 SRAR 的下限（转换数据的平均值 - 2SD）。方差分析定义了组间变异性，线性回归和皮尔逊相关性评估了统计显着性。结果：各年龄组的正常SRAR下限如下：a：0.30，b：0.23，c：0.20，d：0.17，e：0.17，f：0.08。 a、b、c组的SRAR与e、f组有显着差异。同样，SRAR 在 d 组和 f 组之间显着不同，但在 d 组和 e 组或 a、b、c、d 组之间没有显着差异。结论：本研究为SRAR提供了年龄分层的参考数据。有证据表明 SRAR 随年龄而变化；因此，根据此标准诊断周围神经病时不应使用 SRAR 的单一值。
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