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Relation Between the Novel Marker Monocyte to High-Density Lipoprotein Cholesterol Ratio and Severity in Multiple Sclerosis.
Annals of Indian Academy of Neurology ( IF 1.9 ) Pub Date : 2020-05-01 , DOI: 10.4103/aian.aian_249_19
Ersin Kasım Ulusoy 1 , Ömer Faruk Bolattürk 1 , Mehmet Fatih Göl 1
Affiliation  


Introduction: This study aimed to establish whether there is a relationship between the Monocyte to High-Density Lipoprotein Cholesterol (HDL-C) ratio (MHR) and severity of disease, and whether it can be used as a new marker for predicting disability in Multiple Sclerosis (MS), a chronic disease, which is usually contracted in early adolescence. Methods: 184 patient subjects who had been definitively diagnosed with MS, based on the McDonald criteria, and 105 healthy subjects with a similar age and gender profile were included in the study. The patients' Expanded Disability Status Scale (EDSS) scores, MS subtypes, length of time with the disease and demographics were captured. Blood samples were collected for hematologic and biochemical testing. The MHR values were calculated and statistically compared with those of the control group. Results: The average age of the MS patients was 38.3 ± 8.6 years and their average EDSS score was 2.5 [0-7.5]. The patient arm consisted of 118 (64.1%) females and 66 (35.9%) males. In the patients with MS, the MHR was 15.01 ± 0.63 compared to 9.61 ± 0.25 in the controls. This difference was statistically significant (P < 0.001). In the MS patients, the MHR cut-off value was 12.95 compared to controls, which was statistically significant (P < 0.001). Also, a statistically-significant (r: 0.297, P < 0.001) positive correlation was found between the MHR and EDSS score. Conclusion: The Monocyte to High-Density Lipoprotein Cholesterol ratio is associated with disease severity and disability in MS patients, and may be used as an independent marker for predicting disability. However, broader-scale studies are needed for more conclusive results.


中文翻译:

新标记单核细胞与高密度脂蛋白胆固醇比率与多发性硬化症严重程度之间的关系。


简介:本研究旨在确定单核细胞与高密度脂蛋白胆固醇(HDL-C)比率(MHR)与疾病严重程度之间是否存在关系,以及它是否可以作为预测多发性残疾的新标志物。硬化症(MS)是一种慢性疾病,通常在青春期早期患上。方法:本研究纳入了 184 名根据 McDonald 标准明确诊断为 MS 的患者受试者和 105 名年龄和性别相似的健康受试者。记录了患者的扩展残疾状态量表 (EDSS) 评分、MS 亚型、患病时间和人口统计数据。采集血样用于血液学和生化检测。计算MHR值并与对照组进行统计比较。结果: MS 患者的平均年龄为 38.3 ± 8.6 岁,平均 EDSS 评分为 2.5 [0-7.5]。患者组包括 118 名女性 (64.1%) 和 66 名男性 (35.9%)。MS 患者的 MHR 为 15.01 ± 0.63,而对照组为 9.61 ± 0.25。该差异具有统计学意义(P <0.001)。在 MS 患者中,与对照组相比,MHR 截止值为 12.95,具有统计学意义(P < 0.001)。此外, MHR 和 EDSS 评分之间存在统计学显着的正相关性(r:0.297,P < 0.001)。结论:单核细胞与高密度脂蛋白胆固醇比值与MS患者的疾病严重程度和残疾程度相关,可作为预测残疾的独立标志物。然而,需要更广泛的研究才能获得更结论性的结果。
更新日期:2020-05-01
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