Antibacterial Pentacyclic Polyketides from a Soil-Derived Streptomyces.,Journal of Natural Products

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Antibacterial Pentacyclic Polyketides from a Soil-Derived Streptomyces.
Journal of Natural Products ( IF 3.3 ) Pub Date : 2020-06-10 , DOI: 10.1021/acs.jnatprod.0c00161
Jie Yuan _{1,

2} , Li Wang _{1,

3} , Jinqiu Ren _{1,

3} , Jian-Ping Huang ₁ , Mingming Yu _{1,

3} , Jun Tang _{1,

3} , Yijun Yan ₁ , Jing Yang ₁ , Sheng-Xiong Huang ₁

Affiliation

Nine new pentacyclic polyketides, fasamycins G–K (1–5) and formicamycins N–Q (6–9), along with 10 known analogues (10–19), were isolated from a rhizospheric soil-derived Streptomyces sp. KIB-1414. Their structures and absolute configurations were elucidated by interpretation of NMR and HRMS data and comparisons of CD data. The compounds were active against methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus aureus, Bacillus subtilis, and Escherichia coli strains, with MIC values ranging from 0.20 to 50.00 μg/mL.

中文翻译：

来自土壤来源的链霉菌的抗菌五环聚酮化合物。

九个新五环聚酮化合物，fasamycins G-K（1 - 5）和formicamycins的N- Q（6 - 9），用10个已知类似物（沿10 - 19），是从一个根际衍生的分离的链霉菌属。KIB-1414。它们的结构和绝对构型通过对 NMR 和 HRMS 数据的解释以及 CD 数据的比较来阐明。这些化合物对耐甲氧西林金黄色葡萄球菌(MRSA)、金黄色葡萄球菌、枯草芽孢杆菌和大肠杆菌具有活性，MIC 值范围为 0.20 至 50.00 μg/mL。

更新日期：2020-06-26

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