In a recent paper in Cell, Yao et al. used the Mosaic Analysis with Double Markers (MADM) genetic system for granule neuron precursor (GNP) cell-specific simultaneous ablation of the tumor suppressor Tp53 and the expression of fluorescent label in a few cells in a Ptch1-heterozygote, Tp53-heterozygote mouse to track these clonally related populations during development of medulloblastoma.¹ Lineage tracing revealed that tumor-associated astrocytes, as well as medulloblastoma cells, are derived from GNPs. Transcriptome profiling performed by Yao et al. demonstrated that GNP-derived, tumor-associated astrocytes clustered closer to normal astrocytes than GNP-derived tumor cells. Consistent with trans-differentiation of tumor precursors to...

中文翻译：

---

文学亮点

在Cell的最新论文中，Yao等人。所使用的分析马赛克双标记（MADM），用于遗传系统颗粒神经元前体（GNP）肿瘤抑制的特定于小区的同时消融TP53和荧光标记的在少数细胞在表达PTCH1 -heterozygote，Tp53-杂合子小鼠到在髓母细胞瘤的发展过程中追踪这些与克隆相关的人群。¹谱系追踪显示，肿瘤相关的星形胶质细胞和髓母细胞瘤细胞均来自GNP。转录组分析由Yao等人完成。结果表明，与GNP衍生的肿瘤细胞相比，GNP衍生的肿瘤相关星形胶质细胞聚集更接近正常星形胶质细胞。一致反肿瘤前体分化成...