Long-Term Detection of Oncogenic MicroRNA in Living Human Cancer Cells by Gold@ Polydopamine–Shell Nanoprobe,ACS Biomaterials Science & Engineering

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Long-Term Detection of Oncogenic MicroRNA in Living Human Cancer Cells by Gold@ Polydopamine–Shell Nanoprobe
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-06-09 , DOI: 10.1021/acsbiomaterials.0c00633
Wai Ki WONG ₁ , Siu Hong Dexter Wong ₁ , Liming Bian _{1,

2,

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Affiliation

Oncogenic microRNAs (miRNA), for example, miR-155, are key tumor biomarkers in cancer cells that drive tumorigenesis, and the miRNA profile signature can predict cancer development and aggressiveness. Hence, timely detection of oncogenic miRNA in living cells is highly attractive to the diagnosis of cancer at an early stage. Herein, we report a highly sequence-specific gold@polydopamine-based nanoprobe for long-term detection of miRNA in human cancer cell lines in vitro. A single administration of the nanoprobe enables continuous detection of the miR-155 expression level in living cancer cells for up to 5 days. We believe that our nanoprobe is highly promising for both oncology research and translational applications.

中文翻译：

Gold @ Polydopamine-Shell Nanoprobe长期检测人类活细胞中致癌的microRNA

致癌microRNA（miRNA），例如miR-155，是驱动肿瘤发生的癌细胞中的关键肿瘤生物标志物，miRNA谱特征可以预测癌症的发展和侵袭性。因此，及时检测活细胞中的致癌性miRNA对早期诊断癌症非常有吸引力。在此，我们报道了一种高度序列特异性的基于金@聚多巴胺的纳米探针，用于长期检测体外人类癌细胞系中的miRNA 。纳米探针的单次给药能够连续检测存活的癌细胞中miR-155表达水平长达5天。我们相信，我们的纳米探针在肿瘤学研究和转化应用中都具有很高的前景。

更新日期：2020-06-09

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